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Senior Staff

Anthony F. Suffredini, MD
Associate Chief
Critical Care Medicine Department
Medical Director
Critical Care Therapy and Respiratory Care Section
Director
Intensive Care Unit Stat Laboratory, Critical Care Medicine Department

Academic Degrees
BA, Boston University
MD, University of Connecticut

Email: asuffredini@mail.nih.gov

Phone: 301-496-9320

Photo of Anthony Suffredni

Biosketch

Dr. Suffredini came to the Clinical Center in 1984 as a medical staff fellow in the Critical Care Medicine Department. He has held his current position as senior investigator since 1989. He is also on the medical staff of the Washington Hospital Center.

Dr. Suffredini completed his undergraduate studies at Boston University. He attended the University of Rome School of Medicine and graduated from the University of Connecticut School of Medicine. He then completed an internship and residency in internal medicine at the Medical College of Virginia, Richmond, and a fellowship in Critical Care Medicine at the University Health Center of Pittsburgh.

Dr. Suffredini completed his undergraduate studies at Boston University. He attended the University of Rome School of Medicine and graduated from the University of Connecticut School of Medicine. He then completed an internship and residency in internal medicine at the Medical College of Virginia, Richmond, and a fellowship in Critical Care Medicine at the University Health Center of Pittsburgh.

Because of the clinical problem of pulmonary opportunistic infections, his lab group is investigating novel means of detecting fungal pathogens in bronchoalveolar lavage using proteomic methodology. A major on-going collaborative project is investigating the effects of inhaled cyclosporine in hematopoietic stem cell or lung transplant patients with bronchiolitis obliterans.

Dr. Suffredini directed the development of point-of-care ultrasound in the CCMD ICU and has helped to provide regular didactic and hands-on training for members of the department. Dr. Suffredini served one five year term as Associate Editor, American Journal of Respiratory Diseases and Critical Care.

He directs the Clinical Center Endotoxin Repository, which for the last 12 years has been the sole world source of endotoxin for human studies. It has provided endotoxin to over fifty different investigators from biopharmaceutical firms, clinical research facilities, and academic centers as a means to study mechanisms of inflammation, proof of principle for evaluation of novel pharmaceutical or biologic agents, and as an immunoadjuvant for immunotherapy trials of cancer.

He is a co-founder of the Functional Genomics Section and director of the Clinical Proteomics Group in the Critical Care Medicine Department.

He is a founding member and serves on the Organizing Committee of the United States Critical Illness and Injury Trials Group (USCIITG)..

Honors and Awards

NIH Director's Award 2007, NIH Clinical Center Director's Award, 2010, 2004, 1999, 1998; President's Award: Society of Critical Care Medicine. 1999, 1998, 1997, 1996; Fellows Award for Research Excellence, NIH Clinical Center, 1998, 1997; American Federation for Clinical Research, Henry Christian Award for Excellence in Research Presentation, 1990; USPHS Outstanding Unit Citation, 2004, 1994, 1991; USPHS Commendation, 1997, 1994, 1991; USPHS Unit Commendation, 1991

Selected Publications

BOOKS and BOOK CHAPTERS

Seam N, Suffredini AF. The past, present and future of therapies for sepsis and systemic inflammation. In Cavaillion J-M, Adrie C (eds): Sepsis and Non-infectious Systemic Inflammation: From Biology to Critical Care. WILEY-VCH Verlag GmbH & Co. KGaA, Weinham Books 2009.

Munford RS, Suffredini AF. Sepsis, Severe Sepsis and Septic Shock (Chapter 70). In Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases: 7th Edition, Churchill Livingstone, 2009.

JOURNAL ARTICLES

S Talwar, PJ Munson, C Fiuza, Barb J, Cintron P, Logun C, Reda D, RL Danner, AF Suffredini. Gene expression profiling of peripheral blood cells after endotoxin challenge in humans. Physiol Genomics. 2006 ;25:203-15. Epub 2006 Jan 10.

De Torre C, Ying S-X, Munson PJ, Meduri GU, Suffredini AF. Proteomic analysis of inflammatory biomarkers in bronchoalveolar lavage. Proteomics 2006;6:3949 – 57. Epub 2006 June 12.

Raghavachari N, Xu X, Harris A, Villagra J, Logun C, Barb J, Solomon MA, Suffredini AF, Danner RL, Munson PJ, Kato G, Morris S, and Gladwin MT. Amplified expression profiling of platelet transcriptome reveals global activation of arginine degradation pathways in patients with sickle cell disease. Circulation. 2007;115:1551-62. Epub 2007 Mar 12.

Deans KJ, Minneci PC, Suffredini AF, Danner RL, Hoffman WD, Klein HG, Schechter A, Banks SM, Eichacker PQ, and Natanson C. Therapeutic misassignment: a potential confounder of randomized trials investigating routinely titrated therapies. Crit Care Med. 2007;35:1509-1516.

Yuditskaya S, Tumblin A, Hoehn GT, Wang G, Drake SK, Xu X, Ying S-X, Chi AH, Remaley AT, Shen R-F, Munson PJ, Suffredini AF and Kato GJ. Proteomic identification of dysregulated apolipoprotein expression in pulmonary hypertension and vasculopathy of sickle cell disease. Blood 2009;113 1122-1128.

Zhang S, DeGraba TJ, Wang H, Hoehn GT, Gonzales DA, Suffredini AF, Ching W-K, Ng MK, Zhou X, Wong STC. A novel peak detection approach with chemical noise removal using short-time FFT for prOTOF MS data. Proteomics 2009; 9:3833.

Gonzáles DA, De Torre C, Wang H, Devor CB, Munson PJ, Ying S-X, Kern SJ, Petraitiene R, Walsh TJ, and Suffredini AF. Protein expression profiles distinguish between experimental infectious pulmonary aspergillosis and Pseudomonas pneumonia. Proteomics 2010;10: 4270-4280.

Ding Y, Gao ZG, Jacobson KA and Suffredini AF. Dexamethasone enhances ATP-induced inflammatory responses in endothelial cells. J Pharmacol Exp Ther 2010; 335: 693-702.

Barochia AV, Cui X, Vitberg D, Suffredini AF, O’Grady NP, Banks SM, Minneci P, Kern SJ, Danner RL, Natanson C, Eichacker PQ. Bundled care for septic shock: an analysis of clinical trials. Crit Care Med 2010;38:668-78.

Burbelo PD, Seam N, Groot S, Ching KH, Han BL, Meduri GU, Iadarola MJ, and Suffredini AF. Rapid induction of autoantibodies during ARDS and septic shock. J Transl Med 2010;8:97.

Yuditskaya S, Suffredini AF, Kato GJ. The proteome of sickle cell disease: insights from exploratory proteomic profiling. Expert Rev Proteomics. 2010 Dec;7(6):833-48. Review.

Degraba TJ, Hoehn GT, Nyquist PA, Wang H, Kenney R, Gonzales DA, Kern SJ, Ying SX, Munson PJ, Suffredini AF. Biomarker discovery in serum from patients with carotid atherosclerosis. Cerebrovasc Dis Extra. 2011 Jan-Dec;1(1):115-29.

Suffredini AF, Munford RS. Novel therapies for septic shock over the past 4 decades. JAMA. 2011 Jul 13;306(2):194-9.

Seam N, Meduri GU, Wang H, Nylen ES, Sun J, Schultz MJ, Tropea M, Suffredini AF. Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome. Crit Care Med. 2012 Feb;40(2):495-501.

Nyquist PA, Wang H, Suffredini AF. Protein biomarkers in patients with subarachnoid hemorrhage, vasospasm, and delayed ischemic neurological deficits. Acta Neurochir Suppl. 2013;115:23-5.

This page last reviewed on 09/26/12



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