Biosketch

Dr. Suffredini came to the Clinical Center in 1984 as a medical staff fellow in the Critical Care Medicine Department. He has held his current position as senior investigator since 1989. He is also on the medical staff of the Washington Hospital Center.

Dr. Suffredini completed his undergraduate studies at Boston University. He attended the University of Rome School of Medicine and graduated from the University of Connecticut School of Medicine. He then completed an internship and residency in internal medicine at the Medical College of Virginia, Richmond, and a fellowship in Critical Care Medicine at the University Health Center of Pittsburgh.

Dr.Suffredini's research focuses on the investigation of innate immunity and its regulatory mechanisms in pulmonary inflammation, sepsis, and septic shock. He is a co-founder of the Functional Genomics Section and director of the Clinical Proteomics Group in the Critical Care Medicine Department. He is a founding member and serves on the Organizing Committee of the United States Critical Illness and Injury Trials Group (USCIITG).

Honors and Awards

NIH Director’s Award 2007, NIH Clinical Center Director’s Award, 2010, 2004, 1999, 1998; President’s Award: Society of Critical Care Medicine. 1999, 1998, 1997, 1996; Fellows Award for Research Excellence, NIH Clinical Center, 1998, 1997; American Federation for Clinical Research, Henry Christian Award for Excellence in Research Presentation, 1990; USPHS Outstanding Unit Citation, 2004, 1994, 1991; USPHS Commendation, 1997, 1994, 1991; USPHS Unit Commendation, 1991

Selected Publications

BOOKS and BOOK CHAPTERS

Seam N, Suffredini AF. The past, present and future of therapies for sepsis and systemic inflammation. In Cavaillion J-M, Adrie C (eds): Sepsis and Non-infectious Systemic Inflammation: From Biology to Critical Care. WILEY-VCH Verlag GmbH & Co. KGaA, Weinham Books 2009.

Munford RS, Suffredini AF. Sepsis, Severe Sepsis and Septic Shock (Chapter 70). In Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases: 7th Edition, Churchill Livingstone, 2009.

JOURNAL ARTICLES

S Talwar, PJ Munson, C Fiuza, Barb J, Cintron P, Logun C, Reda D, RL Danner, AF Suffredini. Gene expression profiling of peripheral blood cells after endotoxin challenge in humans. Physiol Genomics. 2006 ;25:203-15. Epub 2006 Jan 10.

De Torre C, Ying S-X, Munson PJ, Meduri GU, Suffredini AF. Proteomic analysis of inflammatory biomarkers in bronchoalveolar lavage. Proteomics 2006;6:3949 – 57. Epub 2006 June 12.

Raghavachari N, Xu X, Harris A, Villagra J, Logun C, Barb J, Solomon MA, Suffredini AF, Danner RL, Munson PJ, Kato G, Morris S, and Gladwin MT. Amplified expression profiling of platelet transcriptome reveals global activation of arginine degradation pathways in patients with sickle cell disease. Circulation. 2007;115:1551-62. Epub 2007 Mar 12.

Deans KJ, Minneci PC, Suffredini AF, Danner RL, Hoffman WD, Klein HG, Schechter A, Banks SM, Eichacker PQ, and Natanson C. Therapeutic misassignment: a potential confounder of randomized trials investigating routinely titrated therapies. Crit Care Med. 2007;35:1509-1516.

Yuditskaya S, Tumblin A, Hoehn GT, Wang G, Drake SK, Xu X, Ying S-X, Chi AH, Remaley AT, Shen R-F, Munson PJ, Suffredini AF and Kato GJ. Proteomic identification of dysregulated apolipoprotein expression in pulmonary hypertension and vasculopathy of sickle cell disease. Blood 2009;113 1122-1128.

Zhang S, DeGraba TJ, Wang H, Hoehn GT, Gonzales DA, Suffredini AF, Ching W-K, Ng MK, Zhou X, Wong STC. A novel peak detection approach with chemical noise removal using short-time FFT for prOTOF MS data. Proteomics 2009; 9:3833.

Gonzáles DA, De Torre C, Wang H, Devor CB, Munson PJ, Ying S-X, Kern SJ, Petraitiene R, Walsh TJ, and Suffredini AF. Protein expression profiles distinguish between experimental infectious pulmonary aspergillosis and Pseudomonas pneumonia. Proteomics 2010;10: 4270-4280.

Ding Y, Gao ZG, Jacobson KA and Suffredini AF. Dexamethasone enhances ATP-induced inflammatory responses in endothelial cells. J Pharmacol Exp Ther 2010; 335: 693-702.

Barochia AV, Cui X, Vitberg D, Suffredini AF, O’Grady NP, Banks SM, Minneci P, Kern SJ, Danner RL, Natanson C, Eichacker PQ. Bundled care for septic shock: an analysis of clinical trials. Crit Care Med 2010;38:668-78.

Burbelo PD, Seam N, Groot S, Ching KH, Han BL, Meduri GU, Iadarola MJ, and Suffredini AF. Rapid induction of autoantibodies during ARDS and septic shock. J Transl Med 2010;8:97.