Bradford Wood, MD
NIH Center for Interventional Oncology
Interventional Radiology Section
BA, University of Virginia
MD, University of Virginia
Bradford Wood is Director of the NIH Center for Interventional Oncology, Chief of Interventional Radiology, and a Senior Investigator with Tenure at NIH. He earned both his undergraduate and graduate degrees from The University of Virginia, then completed an Internship in Internal Medicine, followed by Residency in Diagnostic Radiology at Georgetown University, where he was Chief Resident. He then went on to do double fellowships at Massachusetts General Hospital at Harvard in Abdominal Imaging and Intervention and Vascular & Interventional Radiology, and stayed on staff at Massachusetts General Hospital / Harvard after training, and is board-certified in Vascular and Interventional Radiology as well as Diagnostic Radiology.
Dr. Wood has practiced Interventional Radiology at NIH since 1998, when he was recruited from Harvard / Massachusetts General Hospital. He directed the Interventional Radiology Research Lab from 2004 to present, and was Acting Chief of Radiology - Science and Research and Acting Director of the Molecular Imaging Lab from 2006 to 2008. He holds appointments in several NIH institutes, including the NIH Clinical Center and the National Cancer Institute, Urological Oncology Branch, and is credentialed in surgery and radiology. He has received both the Clinical Center Director's Award and the NIH Director's Award, and has published widely in the field of Interventional Radiology and the emerging discipline in Interventional Oncology.
He directs a multidisciplinary team of scientists, students, research nurses, biomedical engineers, computer scientists, chemists, technologists, and physician-scientists within a collaborative environment focused on first in human clinical translational research and development with academic, industry, and government components.
His achievements include All-American in Lacrosse, multiple patents in the field, and pioneering several technologies from the bench to the patient, now in widespread use, including heat deployed chemotherapy combined with thermal ablation for liver cancer, “medical GPS” electromagnetic (EM) tracking for needle-based procedures like biopsy and thermal ablation, and smart needles and devices for minimally invasive, multi-modality, image-guided procedures.
He postulated and implemented bench to bedside Phase I trials of radiofrequency ablation for liver tumors, augmented with heat deployed chemotherapy (heat sensitive liposomal doxorubicin), which is currently post Phase III for hepatocellular carcinoma.
He was among the first physicians to perform radiofrequency ablation for kidney and liver tumors in humans in the mid-1990's, to use ablation devices plus heat-deployed drugs for liver tumors, to guide ablation and biopsy with "GPS-enabled" devices, to combine MRI and ultrasound for fusion guided prostate biopsy, "Medical GPS" fusion-guided ablation and biopsy, and RF ablation for patients with pheochromocytoma, lymphoma, adrenocortical carcinoma, liver abscess, chordoma, and intractable hematuria.
In the 2000's, NIH teams also deployed percutaneous methods for isolated liver perfusion (Chemosaturation) for regional liver therapy. NIH teams have performed over 12,000 needle procedures in over 850 patients with the tracking / fusion technology.
Translational research interests include fusion and navigation tools, minimally-invasive & image-guided tumor ablation tools and treatment planning, drug + device combination therapies, heat deployed nanoparticles activated with needles or ultrasound GPS-enabled medical and surgical devices, image-able drugs (drug eluting beads and liposomes), image-guided robotics, and HIFU for non-invasive ablation or "drug paint-brushing" of chemotherapy.
He is actively involved in the Society of Interventional Radiology and the Radiological Society of North America, and manages numerous government-academic-industry partnerships. He serves on the editorial boards of Interventional Oncology and the Journal of Therapeutic Ultrasound, is on the Board of Directors of the Academy of Radiology Research, and has close collaborations with Duke University, Johns Hopkins University, Harvard / Massachusetts General Hospital, Georgetown University Medical Center, Utrecht Medical Center, Eindhoven University of Technology, Children's National Medical Center, and Innsbruck Medical University. Dr. Wood has been a visiting professor and invited faculty at many institutions around the world.
Dr. Wood has published extensively in the field, coauthoring a book on radiology, over 200 manuscripts and chapters, hundreds of scientific abstracts, and numerous patents or patent applications.
BOOKS AND CHAPTERS
Radiology (House-officer's Handbook Series). 1st Edition. Williams & Wilkins, Baltimore 1998
Wood BJ, Neeman Z, Kam A: New Technologies in Tumor Ablation. in Tumor Ablation: Principles and Practice. E vanSonnenberg, W McMullen (editors). 2006
Cleary K, Buersmeyer T, Wood BJ, Glossop N: Computer Aided Surgery, in: Wiley Encyclopedia of Biomedical Engineering. Metin Akay (editor), John Wiley and Sons, Inc. 2006
Wood BJ, Ramkaransingh JR, Fojo T, Walther MM, Libutti SK: Percutaneous Tumor Ablation with Radiofrequency. Cancer 2002; 94:443-451
Wood BJ, Abraham J, Hvizda JL, Alexander HR, Fojo T: Radiofrequency Ablation of Adrenal Tumors and Adrenocortical Carcinoma Metastases. Cancer 2003, 97:554-60
Pingpank JF, Libutti SK, Chang R, Wood BJ, Neeman Z, Kam AW, Figg WD, Zhai SP, Beresneva T, Seidel GD, Alexander HR: Phase I Study Of Hepatic Arterial Melphalan Infusion And Hepatic Venous Hemofiltration Using Percutaneously Placed Catheters In Patients With Unresectable Hepatic Malignancies. J Clin Oncol 2005;23:3465-3474
Wood BJ, Zhang H, Durrani A, Glossop N, Ranjan S, Lindisch D, Levy E, Banovac F, Borgert J, Krueger S, Kruecker J, Viswanathan A, Cleary K: Navigation with Electromagnetic Tracking for Interventional Radiology Procedures: A Feasibility Study. J Vasc Interven Radiol 2005;16: 493-505
Stone M, Wood BJ: Emerging Local Ablation Techniques: in Special Review: Hepatic Malignancies. Seminars in Vascular and Interventional Radiology 2006;23:425-428
Sudheendra D, Barth M, Hegde U, Wilson W, Wood BJ: Radiofrequency Ablation of Lymphoma. Blood 2006;107:1624-1626
Dromi S, Frenkel V, Luk A, Traughber B, Angstadt M, Bur M, Poff J, Xie J, Libutti SK, Li KCP, Wood BJ: Pulsed-high intensity focused ultrasound and low temperature sensitive liposomes for enhanced targeted drug delivery and anti-tumor effect. Clin Cancer Res 2007;13:2722-2727
Wood BJ, Locklin JK, Viswanathan A, Kruecker J, Haemmerich D, Cebral J, Sofer A, Cheng R, McCreedy E, Cleary K, McAuliffe MJ, Glossop N, Yanof J: Technologies for Guidance of Radiofrequency Ablation in the Multimodality Interventional Suite of the Future. J Vasc Interv Radiol 2007;18:9-24
Krücker J, Xu S, Glossop N, Viswanathan A, Borgert J, Schulz H, Wood BJ: Electromagnetic tracking for thermal ablation and biopsy guidance: clinical evaluation of spatial accuracy. J Vasc Interv Radiol 2007;18:1141-1150
Singh A, Kruecker J, Xu S, Glossop N, Guion P, Ullman K, Choyke P, Wood BJ: Initial Clinical Experience with Real Time Ultrasound-MRI Fusion-Guided Prostate Biopsy. British Journal of Urology International 2008;101:841-845
Dromi SA, Herby S, Walsh M, Dreher M, Xie J, Fry T, Wood BJ: Radiofrequency Ablation Induces Antigen Presenting Cell Infiltration and Amplification of Weak Tumor-Induced Immunity, Radiology 2009; 251:58-66
Wood BJ, Venkatesan A, Locklin J, Amalou H, Glossop N, , Xu S, Kruecker J: Navigation Systems for Ablation. J Vasc Interv Radiol 2010; 21:S257-63
Kruecker J, Xu S, Venkatesan A, Locklin J, Amalou H, Glossop N, Wood BJ: Clinical Utility of Real-Time Fusion Guidance for Biopsy and Ablation. J Vasc Interv Radiol 2011;22:515-24
Sharma KV, Dreher MR, Tang Y, Pritchard W, Chiesa OA, Karanian J, Perogoy J, Orandi B, Woods D, Donahue D, Esparza J, Jones G, Willis SL, Lewis AL, Wood B: Development of "imageable" beads for transcatheter embolotherapy. J Vasc Interv Radiol 2010;21:865-76
Venkatesan AM, Locklin J, Lai EW, Adams KT, Fojo AT, Pacak K, Wood BJ: Radiofrequency ablation of metastic pheochromocytoma. J Vasc Interv Radiol 2009; 20: 1483-90
Negussie AH, Yarmolenko PS, Partanen A, Ranjan A, Jacobs G, Woods D, Bryant H, Thomasson D, Dewhirst MW, Wood BJ, Dreher MR: Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. Int J Hyperthermia. 2011;27:140-55
Pinto PA, Chung PH, Rastinehad AR, Baccala AA, Kruecker J, Xu S, Yan P, Kadoury S, Chua C, Locklin JK, Turkbey B, Shih JH, Gates SP, Buckner C, Bratslavsky G, Linehan WM, Glossop ND, Choyke PL, Wood BJ: MRI/Ultrasound Fusion Guided Prostate Biopsy Improves Cancer Detection Following TRUS Biopsy and Correlates with Multiparametric MRI. J Urol. 2011 Oct;186(4):1281-5
Venkatesan AM, Wood BJ, Gervais DA: Percutaneous Ablation in the Kidney. Radiology Percutaneous ablation in the kidney. Radiology. 2011 Nov;261(2):375-91
Venkatesan AM, Kadoury S, Abi-Jaoudeh N, Levy EB, Maass-Moreno R, Krücker J, Dalal S, Xu S, Glossop N, Wood BJ: Real-time FDG PET Guidance during Biopsies and Radiofrequency Ablation Using Multimodality Fusion with Electromagnetic Navigation. Radiology. 2011 Sep;260(3):848-56
Abi-Jaoudeh N, Kruecker J, Kadoury S, Kobeiter H, Venkatesan AM, Levy E, Wood BJ: Multimodality Image Fusion-Guided Procedures: Technique, Accuracy, and Applications. Cardiovasc Intervent Radiol. 2012;35:986-98
Partanen A, Yarmolenko PS, Viitala A, Appanaboyina S, Haemmerich D, Ranjan A, Jacobs G, Woods D, Enholm J, Wood BJ, Dreher MR: Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery. Int J Hyperthermia. 2012;28(4):320-336
Dreher MR, Sharma KV, Woods DL, Reddy G, Tang Y, Pritchard WF, Chiesa OA, Karanian JW, Esparza JA, Donahue D, Levy EB, Willis SL, Lewis AL, Wood BJ: Radiopaque Drug-Eluting Beads for Transcatheter Embolotherapy: Experimental Study of Drug Penetration and Coverage in Swine. J Vasc Interv Radiol. 2012 Feb;23(2):257-64
Turkbey B, Xu S, Kruecker J, Locklin J, Pang Y, Bernardo M, Merino MJ, Wood BJ, Choyke PL, Pinto PA: Documenting the location of prostate biopsies with image fusion. BJU Int. 2011 Jan;107(1):53-7
Vourganti S, Rastinehad A, Yerram NK, Nix J, Volkin D, Hoang A, Turkbey B, Gupta GN, Kruecker J, Linehan WM, Choyke PL, Wood BJ, Pinto PA:.Multiparametric Magnetic Resonance Imaging and Ultrasound Fusion Biopsy Detect Prostate Cancer in Patients with Prior Negative Transrectal Ultrasound Biopsies. J Urol. 2012 Oct 17 [Epub ahead of print]
Amalou H, Wood BJ: Biopsy and personalized medicine. Nature Reviews Gastroenterol Hepatol.2012: Oct 2 [Epub ahead of print]
Gasselhuber A, Dreher MR, Rattay F, Wood BJ, Haemmerich D: Comparison of conventional chemotherapy, stealth liposomes and temperature-sensitive liposomes in a mathematical model.PLoS One 2012;7(10): Oct 17 Epub 2012 Oct 17
Wood BJ, Poon RT, Locklin J, Dreher MR, Ng KK, Eugeni M, Seidel G, Dromi S, Neeman Z, Kolf M, Black CDV, Prabhakar R, Libutti SK: A Phase I Study of Heat Deployed Liposomal Doxorubicin during Radiofrequency Ablation for Hepatic Malignancies. J Vasc Interv Radiol. 2012 Feb;23(2):248-55