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Senior Staff

Robert L. Danner, MD
Senior Investigator
Head, Infectious Diseases Section and
Continuous Renal Replacement Therapy Service
Director, Functional Genomics Facility
Critical Care Medicine Department

Academic Degrees
BA, Johns Hopkins University
MD, Cornell University

Email: rdanner@cc.nih.gov

Phone: 301-496-9320

Portrait of Robert L. Danner, MD

Biosketch

Dr. Robert L. Danner MD heads the Infectious Diseases Section and Continuous Renal Replacement Therapy Service of the Critical Care Medicine Department at the NIH Clinical Center. He became a Senior Investigator at NIH in 1988 and holds the rank of Clinical Professor of Medicine at Georgetown University Medical Center.

Dr. Danner is a Special Consultant to the Food and Drug Administration and a member of the Editorial Advisory Board of Journal of Infectious Diseases. He has also served as a member of the Food and Drug Administration's Anti-Infective Drug Products Advisory Committee, the Editorial Board of Critical Care Medicine, and the Society of Critical Care Medicine's Continuing Education Committee. Dr. Danner is a past Chair of the Critical Care Medicine Test Committee and a former Director on the American Board of Internal Medicine.

Dr. Danner received his undergraduate degree in Biology from Johns Hopkins University and his degree in Medicine from Cornell University. He then completed residency training in Internal Medicine at New York Hospital / Cornell University Medical Center. Fellowship training in Critical Care Medicine and Infectious Diseases was completed at NIH and Children's National Medical Center.

Septic shock and multiple organ failure are long-term research interests of Dr. Danner's section. Recent investigations have focused on nitric oxide and carbon monoxide as endogenous regulators of inflammation, nuclear receptor trans-repression as a means to target vascular inflammation and the functional genomics of critical illness and injury. Dr. Danner directs the Functional Genomics Facility in the Critical Care Medicine Department at the NIH Clinical Center.

Honors and Awards

Society of Critical Care Medicine presidential citation for outstanding contributions, 2007; Consumer's Research Council of America, top physician, 2006, 2007, 2008, 2009 and 2010; NIH Director's Award, 2006; U.S. Public Health Service crisis response service award, Gulf Coast hurricanes, 2005; USPHS Outstanding Unit Citation, 2003; USPHS Outstanding Service Medal (clinical medicine and research), 2000; American Federation for Clinical Research Henry Christian Award for abstract in immunology, 1999 and 1998; USPHS Achievement Medal, 1997; USPHS Commendation Medal, 1994 and 1990; Society of Critical Care Medicine Education Scholarship Award, 1993; The AFCR Henry Christian Award poster presentation, 1991; Alpha Omega Alpha, 1979; Phi Beta Kappa, 1975.

Selected Publications

Journal Articles

Danner RL, Joiner KA, Parrillo JE. The inhibition of endotoxin induced priming of human neutrophils by lipid X and 3-aza-lipid X. The Journal of Clinical Investigation 80:605-612, 1987.

Natanson C, Danner RL, Elin RJ, Hosseini JM, Peart KW, MacVittie TJ, Walker RI, Parrillo JE. The role of endotoxemia in cardiovascular dysfunction and mortality. E. coli and S. aureus challenges in a canine model of human septic shock. The Journal of Clinical Investigation 83:243-251, 1989.

Natanson C, Eichenholz PW, Danner RL, Eichacker PQ, Hoffman WD, Kuo GC, Banks SM, MacVittie TJ, Parrillo JE. Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. Journal of Experimental Medicine 169:823-832, 1989.

Doerfler ME, Danner RL, Shelhamer JH, Parrillo JE. Bacterial lipopolysaccharides prime human neutrophils for enhanced production of leukotriene B4. The Journal of Clinical Investigation 83:970-977, 1989.

Danner RL, Elin RJ, Wesley RA, Reilly JM, Hosseini JM, Parrillo JE. Endotoxemia in human septic shock. Chest 99:169-175, 1991.

Martich GD, Danner RL, Ceska M, Suffredini AF. Detection of interleukin-8 and tumor necrosis factor in normal humans following intravenous endotoxin: The effect of anti-inflammatory agents. Journal of Experimental Medicine 173:1021-1024, 1991.

Warren SW, Danner RL, Munford RS. Anti-endotoxin monoclonal antibodies. New England Journal of Medicine 326:1153-1157, 1992.

Van Dervort AL, Doerfler ME, Stuetz PL, Danner RL. Antagonism of lipopolysaccharide-induced priming of human neutrophils by lipid A analogs. Journal of Immunology 149:359-366, 1992.

Cobb JP, Natanson C, Hoffman WD, Lodato RF, Banks SM, Koev LA, Solomon M, Elin RJ, Hosseini JM, Danner RL. NW-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin. Journal of Experimental Medicine 176:1175-1189, 1992.

Taveira da Silva AM, Kaulbach H, Chuidian F, Lambert D, Suffredini AF, Danner RL. Shock and multiple organ dysfunction caused by self-administration of Salmonella minnesota endotoxin. New England Journal of Medicine 328:1457-1460, 1993.

Quezado ZMN, Natanson C, Alling DW, Banks SM, Koev CA, Elin RJ, Hosseini JM, Bacher JD, Danner RL, Hoffman WD. A controlled trial of HA-1A in a canine model of gram-negative septic shock. Journal of the American Medical Association 269:2221-2227, 1993.

Van Dervort AL, Yan L, Madara PJ, Cobb JP, Wesley RA, Corriveau CC, Tropea MM, Danner RL. Nitric oxide regulates endotoxin-induced TNF-α production in human neutrophils. Journal of Immunology 152:4102-4109, 1994.

Danner RL. Nitric oxide: a therapeutic target in sepsis. In: Natanson C, moderator. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Annals of Internal Medicine 120:771-783, 1994.

Yan L, Vandivier RW, Suffredini AF, Danner RL. Human polymorphonuclear leukocytes lack detectable nitric oxide synthase activity. Journal of Immunology 153:1825-1834, 1994.

Wang S, Yan L, Wesley RA, Danner RL. Nitric oxide increases tumor necrosis factor production in differentiated U937 cells by decreasing cAMP. Journal of Biological Chemistry 272(9): 5959-5965, 1997.

Sevransky JE, Shaked G, Novogrodsky A, Levitzki A, Gazit A, Hoffman A, Elin RJ, Quezado ZMN, Freeman BD, Eichacker PQ, Danner RL, Banks SM, Bacher J, Thomas ML III, and Natanson C: Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis. Journal of Clinical Investigation 99: 1966-1973, 1997.

Yan L, Wang S, Rafferty SP, Wesley RA, Danner RL. Endogenously produced nitric oxide increases tumor necrosis factor-a production in transfected human U937 cells. Blood 90:1160-1167, 1997.

Vandivier RW, Eidsath A, Banks SM, Preas HL, Leighton SB, Godin PJ, Suffredini AF, and Danner RL. Down-regulation of nitric oxide production by ibuprofen in human volunteers. Journal of Pharmacology and Experimental Therapeutics 289:1398-1403, 1999.

Wang S, Wang W, Wesley RA, Danner RL. A Sp1 binding site of the TNF-α promoter functions as a nitric oxide-response element. Journal of Biological Chemistry 274:33190-33193, 1999.

Wang W, Wang S, Yan L, Madara P, Cintron ADP, Wesley RA, Danner RL. Superoxide production and signaling by endothelial nitric oxide synthase. Journal of Biological Chemistry 274:16899-16903, 2000.

Wang W, Wang S, Nishanian EV, del Pilar Cintron A, Wesley RA, Danner RL. Signaling by eNOS through a superoxide-dependent p42/44 mitogen-activated protein kinase pathway. American Journal of Physiology-Cell Physiology 281:C544-C554, 2001.

Eichacker PQ, Parent C, Esposito C, Kalil A, Cui X, Banks SM, Gerstenberger EP, Danner RL, Natanson C. Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis. American Journal of Respiratory and Critical Care Medicine 166:1197-1205, 2002.

Zhang J, Wang S, Wesley RA, Danner RL. Adjacent sequence controls the response polarity of nitric oxide-sensitive Sp factor binding sites. Journal of Biological Chemistry 278:29192-29200, 2003.

Ma P, Cui X, Nishanian EV, Wang W, Zhang J, Wesely RA, Wang S, Danner RL. Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 gene expression through p38 MAPK activation. Journal of Leukocyte Biology 76: 278-287, 2004.

Jison ML, Munson PJ, Barb JJ, Suffredini AF, Talwar S, Logun C, Raghavachari N, Beigel JH, Shelhamer JH, Danner RL, Gladwin MT. Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic and inflammatory stress of sickle cell disease. Blood 104: 270-280, 2004.

Cui X, Zhang J, Ma P, Myers DE, Goldberg IG, Sittler KJ, Barb JJ, Munson PJ, Cintron AP, McCoy JP, Wang S, Danner RL. cGMP-independent nitric oxide signaling and regulation of the cell cycle. BMC Genomics 6:151-169, 2005.

Talwar S, Munson PJ, Barb J, Fiuza C, Cintron AP, Logun C, Tropea M, Khan S, Reda D, Shelhamer JH, Danner RL,Suffredini AF. Gene Expression profiling of peripheral blood leukocytes after endotoxin challenge in humans. Physiological Genomics 25(2):203-215, 2006.

Wang S, Zhang J, Theel S, Barb JJ, Munson PJ, Danner RL. Nitric Oxide activation of Erk ½ regulates the stability and translation of mRNA transcripts containing CU-rich elements. Nucleic Acids Research 34(10):3044-3056, 2006.

Eichaker PQ, Natanson C, Danner RL. Surviving sepsis-practice guidelines, marketing, campaigns, and Eli Lilly. New England Journal of Medicine 355(16):1640-1642, 2006.

Zhang J, Wang S, Kern S, Cui X, Danner RL. Nitric oxide down-regulates polo-like kinase 1 through a proximal promoter cell cycle gene homology region. Journal of Biological Chemistry 282(2):1003-1009, 2006.

Ptasinka A, Wang S, Zhang J, Danner RL. Nitric Oxide activation of peroxisone proliferator activated receptor gamma through a p38 MAPK signaling pathway. FASEB Journal 21:950-961, 2007.

Raghavachari N, Xu X, Harris A, Villagra J, Logun C, Barb J, Solomon MA, Suffredini AF, Danner RL, Munson PJ, Kato G, Morris SM, Gladwin MT. Amplified expressions profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation 115(2):1551-1562, 2007.

Oliveira JB, Bidere N, Niemela JE, Zheng L, Sakai K, Nix CP, Danner RL, Barb J, Munson PJ, Puck JM, Dale J, Straus SE, Fleisher TA, Lenardo MJ. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proceedings of the National Academy of Science U.S.A. 104(21):8953-8, 2007.

Wang S, Zhang J, Zhang Y, Kern S, Danner RL. Nitric oxide-p-38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms. Journal of Leukocyte Biology 83(4):982-90, 2008.

Hinrichs CS, Borman ZA, Cassard L, Gattinoni L, Spolski R, Yu Z, Sanchez-Perez L, Muranski P, Kern SJ, Logun C, Palmer DC, Ji Y, Reger RN, Leonard WJ, Danner RL, Rosenberg SA, Restifo NP. Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. Proceedings of the National Academy of Science U.S.A. 106(41):17469-74, 2009.

Chhikara M, Wang S, Kern SJ, Ferreyra GA, Barb JJ, Munson PJ, Danner RL. Carbon monoxide blocks lipopolysaccharide-induced gene expression by interfering with proximal TLR4 to NF-kappaB signal transduction in human monocytes. PLoS One 4(12):e8139, 2009.

Brochard L, Abroug F, Brenner M, Broccard AF, Danner RL, Ferrer M, Laghi F, Magder S, Papazian L, Pelosi P, Polderman KH. An Official ATS/ERS/ESICM/SCCM/SRLF Statement: Prevention and Management of Acute Renal Failure in the ICU Patient: an international consensus conference in intensive care medicine. American Journal of Respiratory and Critical Care Medicine 181(10):1128-55, 2010.

Rame JE, Barouch LA, Sack MN, Lynn EG, Abu-Asab M, Tsokos M, Kern SJ, Barb JJ, Munson PJ, Halushka MK, Miller KL, Fox-Talbot K, Zhang J, Hare JM, Solomon MA, Danner RL. Caloric Restriction in Leptin Deficiency Does Not Correct Myocardial Steatosis: Failure to Normalize PPAR{alpha}/PGC1{alpha} and Thermogenic Glyecrolipid/Fatty Acid Cycling. Physiological Genomics Mar 22, 2011 [Epub ahead of print].

Prasad P, Sun J, Danner RL, Natanson C. Excess deaths associated with tigecycline after approval based on noninferiority trials. Clin Infect Dis. 2012 Jun;54(12):1699-709. Epub 2012 Mar 30.

This page last reviewed on 09/26/12



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