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Senior Staff

Thomas A. Fleisher, MD
Chief
Department of Laboratory Medicine
Chief
Immunology Service, DLM

Academic Degrees
BS, MD, University of Minnesota

Email: tfleishe@mail.nih.gov

Phone: 301-496-5668

Portrait of Thomas Fleisher

Biosketch

Dr. Thomas A. Fleisher received his medical and pediatric training at University of Minnesota and went on for training in immunology at NIH in the laboratory of Dr. Thomas Waldmann. Following this training and a brief faculty position at Walter Reed Army Medical Center, he was chosen to direct the Clinical Immunology Laboratory in the Department of Laboratory Medicine at NIH. In 1998, he was selected as chief of the Department of Laboratory Medicine, where he also continues to run the immunology service within the department.

Dr. Fleisher is an adjunct professor of pediatrics at Uniformed University of the Health Sciences, and serves as consultant to the Allergy Immunology Department at Walter Reed. He served as a member of the board of directors of the American Board of Allergy and Immunology from 1991-2000 and was elected chair of the board in 1996. He also was a member of the American Board of Pediatrics. He was on the executive committee of the Clinical Immunology Society from 2003-2006, having served as its president in 2005, was a member of the board of directors of the American Academy of Allergy, Asthma and Immunology from 2003-2007 and was President of the Robert A. Good Immunology Society from 2008-2010.

His research interests focus on improving current assays and developing new diagnostic methods in laboratory immunology, particularly as they pertain to immune deficiency disorders. Dr. Fleisher is a member of a group of NIH medical scientists who described and characterized the autoimmune lymphoproliferative syndrome (ALPS).

Dr. Fleisher served as the editor in chief of the Journal of Clinical Immunology from 2011-2012 and is on the editorial board of Current Opinion in Allergy and Clinical Immunology, Clinical Immunology, Clinical and Laboratory Immunology, and Communications in Clinical Cytometry. Dr. Fleisher is a co-editor of Clinical Immunology: Principles and Practice, the fourth edition of which is currently in press. Dr. Fleisher has published more than 200 peer reviewed manuscripts, reviews, and chapters.

Honors and Awards

Distinguished Service Award (American Academy of Allergy, Asthma and Immunology [AAAAI]), 2013; NIH Clinical Center Director's Award, 2010, 2011, 2012; Carl E. Arbesman Memorial Lectureship (AAAAI), 2008; Richard Farr Lecture (Colorado Allergy Society), 2003; NIH Director's Award, 1998; Dees Symposium Lecture (Duke University Medical School), 1998, 2005; Carl E. Arbesman Memorial Lectureship (AAAAI), 1998; Best Doctors in America,1994, 2003, 2007, 2010; Who¹s Who in America, 1993-present; Outstanding Service Medal, USPHS, 1992; Commendation Medal, USPHS, 1986

Selected Publications

BOOK CHAPTERS

Oliveira JB, Fleisher TA.  Flow cytometry. In  Fleisher TA, Frew A, Rich RR, Schroeder H, Shearer WT, Weyand C eds. Clinical Immunology: Principles and Practice (3rd edition).  Elsevier, London. pp 1435-1446, 2008.

Fleisher TA. Evaluation of suspected immunodeficiency. Schlossberg D, ed. Clinical Infectious Diseases. Cambridge University Press, New York, NY. Pp 587-592, 2008

Chinen J, Fleisher T, Shearer WT.  The immune system: an overview.  In Adkinson NF Jr, Yunginger JW, Busse WW, Bochner BS, Holgate ST, Simmons FER eds.  Middleton’s Allergy: Principles and Practice (7th edition). Elsevier. Philadelphia. Pp 3-18, 2009.

Rao K and Fleisher TA. Autoimmune lymphoproliferative syndrome. In Strober W and Gottesman SRS eds. Immunology: Clinical Case Studies and Disease Pathophysiology. Wiley-Blackwell, Hoboken, NJ. pp 81-90, 2009.

Fleisher TA. Basic principles and clinical applications of flow cytometry. In Rodgers G and Young NS, eds. Bethesda Handbook of Clinical Hematology 2nd edition. Lippincott Williams & Wilkins, Baltimore, MD. pp 402-411, 2010.

Oliveira JB, Torgerson T, Fleisher TA. Congenital immunedysregulation disorders. In  Leung DYM, Geha R, Sampson H, Szefler S (eds). Pediatric Allergy: Principles and Practice 2nd ed.  Elsevier, London. pg 170-178, 2010.

Ballow M, Fleisher TA. Secondary immune deficiency induced by drugs and biologics. In Feldweg AM, ed. UpToDate. Waltham, MA. In press.

Fleisher TA, Oliveira, JB, Bleesing JJH. Diagnostic Immunology. In Adelman DC, Casale TB, Corren J. Manual of Allergy and Immunology (5th edition). Lippincott Williams and Wilkins. Philadelphia. In press.

JOURNAL ARTICLES

Olivier JB, Bidere N, Niemela JE, Zheng L, Sakai K, Nix CP, Danner RL, Barb J, Munson PJ, Puck JM, Dale J, Straus SE, Fleisher TA, Lenard MJ. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proc Nat Acad Sci (USA). 104: 8953-8958, 2007.

Rao VK, Dowdell KC, Dale JK, Dugan F, Pesnicak L, Bi LL, Hoffmann V, Penzak S, Avila NA, Fleisher TA, Puck JM, Straus SE. Pyrimethamine treatment does not ameliorate lymphoproliferation or autoimmune disease in MRL/lpr-/- mice or in patients with autoimmune lymphoproliferative syndrome. Am J Hematol. 82:1049-1055, 2007.

Uzel G, Tng E, Rosenzweig SD, Hsu AP, Shaw JP, Horwitz ME, Linton GF, Anderson SM, Kirby MR, Oliveira JB, Brown MR, Fleisher TA, Law SK, Holland SM. Reversion mutations in patients with leukocyte adhesion deficiency type I (LAD-I). Blood. 111:211-219, 2008.

Marques A, Brown M, Fleisher TA. Natural killer cell counts are not different between patients with post-Lyme disease syndrome and controls. Clin Vaccine Immunol. 16:1249-50, 2009.

Luangwedchakarn v, Jirapongsaranuruk O, Niemela JE, Thepthai, C, Chokephaibulkit K, Sukpanichnant S, Pacharn P, Visitsunthorn N, Vichyanond P, Piboonpocanun S, Fleisher TA. A novel mutation of the IL-12RB1 gene in a child with nocardiosis, recurrent slamonellosis and neurofibromatosis type 1: first case report from Thailand. Asian Pac J Allergy Immunol. 27:161-165, 2009.

Caminha I, Fleisher TA, Hornung RL, Niemela JE, Price S, Davis J, Perkins K, Dowdell KC, Brown MR, Rao VK, Oliveira JB. The use of biomarkers to predict the presence of FAS mutations inpatients with autoimmune lympho-proliferative syndrome (ALPS). J Allergy Clin Immunol.125:945-949, 2010.

Dowdell KC, Niemela JE, Price S, Davis J, Hornung RL, Oliveira JB, Puck JM, Jaffe ES, Pittaluga S, Chohen JI, Fleisher TA, Rao VK. Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome. Blood. 115:5164-5169, 2010.

Oliveira JB, Bleesing JHH, Dianzani U, Fleisher TA, Jaffe ES, Lenardo MJ, Rieux-Laucat F, Siegel RM, Su HC, Teachey DT, Rao VK. Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop. Blood 116: e35-40. 2010.

Niemela JE, Lu L, Fleisher TA, Davis J, Caminha I, Natter M, Beer LA, Dowdell KC, Pitaluga S, Raffeld M, Rao VK, Oliveira JB. Somatic KRAS mutations associated with a human non-malignant syndrome of autoimmunity and abnormal leukocyte homeostasis. Blood. (Nov 15 Epub), 2010.

Heim KF, Fleisher TA, Stroncek DF, Holland SM, Gallin JI, Malech HL, Leitman SF. The relationship between alloimmunization and posttransfusion granulocyte survival: experience in a chronic granulomatous disease cohort. Transfusion. (Dec 22 Epub), 2010.

Kuehn HS, Caminha I, Niemela JE, Rao VK, Davs J, Fleisher TA, Oliveira JB. FAS haploinsufficiency is a common disease mechanism in the human autoimmune lymphoproliferative syndrome. J Immunol. (April 13, Epub), 2011.

This page last reviewed on 02/27/13



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