NIH Clinical Center Senior Staff
Thomas A. Fleisher, MD
Dr. Thomas A. Fleisher received his medical and pediatric training at University of Minnesota and went on for training in immunology at NIH in the laboratory of Dr. Thomas Waldmann. Following this training and a brief faculty position at Walter Reed Army Medical Center, he was chosen to direct the Clinical Immunology Laboratory in the Department of Laboratory Medicine at NIH. In 1998, he was selected as chief of the Department of Laboratory Medicine, where he also continues to run the immunology service within the department.
Dr. Fleisher is an adjunct professor of pediatrics at Uniformed University of the Health Sciences, and serves as an attending physician for the NIAID allergy immunology consult service. He served as a member of the board of directors of the American Board of Allergy and Immunology from 1991-2000 and was elected chair of the board in 1996. He also was a member of the American Board of Pediatrics. He was on the executive committee of the Clinical Immunology Society from 2003-2006, having served as its president in 2005, was a member of the board of directors of the American Academy of Allergy, Asthma and Immunology (AAAAI) from 2003-2007 and will be President of the AAAAI staring in 2016.
His research interests focus on improving current assays and developing new diagnostic methods in laboratory immunology, particularly as they pertain to immune deficiency disorders and defining new primary immune deficiency disorders. Dr. Fleisher is a member of a group of NIH medical scientists who described and characterized the autoimmune lymphoproliferative syndrome (ALPS) and more recently other related conditions.
Dr. Fleisher served as the editor in chief of the Journal of Clinical Immunology from 2011-2012 and has served on the editorial boards of Current Opinion in Allergy and Clinical Immunology, Clinical Immunology, Clinical and Laboratory Immunology, and Communications in Clinical Cytometry. Dr. Fleisher is a co-editor of Clinical Immunology: Principles and Practice, the fourth edition of which is was published in 2013. He has authored or co-authored more than 250 peer reviewed manuscripts, reviews, and chapters.
Honors and Awards
President’s Award (Clinical Immunology Society) 2015; Erwin Netter Lecture (Association of Medical Laboratory Immunologists) 2014; Distinguished Service Award (AAAAI) 2013; NIH Clinical Center Director's Award, 2010, 2011, 2012; Carl E. Arbesman Memorial Lectureship (AAAAI) 2008; Richard Farr Lecture (Colorado Allergy Society, 2003; NIH Director's Award 1998; Dees Symposium Lecture (Duke University Medical School),1998, 2005; Carl E. Arbesman Memorial Lectureship (AAAAI) 1998; Best Doctors in America 1994, 2003, 2007, 2010, 2014; Who's Who in America 1993-present; Outstanding Service Medal, USPHS, 1992; Commendation Medal, USPHS, 1986.
Oliveira JB, Torgerson T, Fleisher TA. Congenital immunedysregulation disorders. In Leung DYM, Geha R, Sampson H, Szefler S (eds). Pediatric Allergy: Principles and Practice (2nd edition) Elsevier, London. In press.
Fleisher TA. Evaluation of suspected immunodeficiency. Schlossberg D, ed. Clinical Infectious Diseases (2nd edition). Cambridge University Press, New York, NY. In press.
Chinen J, Fleisher T, Shearer WT. Adaptive Immunity. In Adkinson NF Jr, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, O'Hehir RE eds. Middleton's Allergy: Principles and Practice (8th edition). Elsevier. Philadelphia. Pp 20-29, 2014.
Oliveira JB, Fleisher TA. Flow cytometry. In Fleisher TA, Frew A, Rich RR, Schroeder H, Shearer WT, Weyand C eds. Clinical Immunology: Principles and Practice (4th edition). Elsevier, London. pp 1160-11716, 2013.
Fleisher TA, Braylan R. Basic principles and clinical applications of flow cytometry. In Rodgers G and Young NS, eds. Bethesda Handbook of Clinical Hematology (3rd edition). Lippincott Williams & Wilkins, Baltimore, MD. pp 427-440, 2013.
Fleisher TA, Oliveira, JB, Bleesing JJH. Diagnostic Immunology. In Adelman DC, Casale TB, Corren J. Manual of Allergy and Immunology (5th edition). Lippincott Williams and Wilkins. Philadelphia. Pp 393-417, 2012.
Ballow M, Fleisher TA. Secondary immune deficiency induced by drugs and biologics. In Feldweg AM, ed. UpToDate. Waltham, MA.
Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, Schickel JN, Tran DQ, Stoddard J, Zhang Y, Frucht DM, Dumitriu B, Scheinberg P, Folio LR, Frein CA, Price S, Koh C, Heller T, Seroogy CM, Huttenlocher A, Rao VK, Su HC, Kleiner D, Notarangelo LD, Rampertaap Y, Olivier KN, McElwee J, Hughes J, Pittaluga S, Oliveira JB, Meffre E, Fleisher TA, Holland SM, Lenardo MJ, Tangye SG, Uzel G. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science. 345: 1623-1627, 2014.
Pai SY, Logan BR, Griffith LM, Buckley RH, Parrott RE, Dvorak CC, Kapoor N, Hanson IC, Filipovich AH, Jyonouchi S, Sullivan KE, Small TN, Burroughs L, Skoda-Smith S, Haight AE, Grizzle A, Pulsipher MA, Chan KW, Fuleihan RL, Haddad E, Loechelt B, Aquino VM, Gillio A, Davis J, Knutsen A, Smith AR, Moore TB, Schroeder ML, Goldman FD, Connelly JA, Porteus MH, Xiang Q, Shearer WT, Fleisher TA, Kohn DB, Puck JM, Notarangelo LD, Cowan MJ, O'Reilly RJ. Transplantation outcomes for severe combined immunodeficiency: 2000-2009. N Engl J Med. 37:434-446, 2014.
Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Montealegre Sanchez GA, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CC, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 371:507-518, 2014.
Medical Advisory Committee of the Immune Deficiency Foundation, Shearer WT, Fleisher TA, Buckley RH, Ballas Z, Ballow M, Blaese RM, Bonilla FA, Conley ME, Cunningham-Rundles C, Filipovich AH, Fuleihan R, Gelfand EW, Hernandez-Trujillo V, Holland SM, Hong R, Lederman HM, Malech HL, Miles S, Notarangelo LD, Ochs HD, Orange JS, Puck JM, Routes JM, Stiehm ER, Sullivan K, Torgerson T, Winkelstein J. Recommendations for live viral bacterial vaccines in immunodeficiency patients and their close contacts. J Allergy Clin Immunol. 133:961-966, 2014.
Price S, Shaw PA, Seitz A, Joshi G, Davis J, Niemela JE, Perkins K, Hornung RL, Folio L, Rosenberg PS, Puck JM, Hsu AP, Lo B, Pittaluga S, Jaffe ES, Fleisher TA, Rao VK, Lenardo MJ. Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations. Blood. 1223:1989-1999, 2014.
Shearer WT, Dunn E, Notarangelo LD, Dvorak CC, Puck JM, Logan BR, Griffith LM, Kohn DB, O'Reilly RJ, Fleisher TA, Pai SY, Martinez CA, Buckley RH, Cowan MJ. Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID): the Primary Immun Deficiency Treatment Consortium experience. J Allergy Clin Immunol. 133:1092-1098, 2014.
Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G. Dominant-activating gene mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Nat Immunol. 15:88-97, 2014.
Dvorak CC, Cowan MJ Logan BR, Notarangelo LD, Griffith LM, Puck JM, Kohn DB, Shearer WT, Pai S-Y, Fleisher TA, Plusipher MA, Goldman F, Fuleihan R, Filipovich A, Kapoor N, O’Reilly R, Smith A, Knutsen A, Sullivan K, Loechelt B, Cuvelier G, Chan K-W, Buckley RH. The natural baseline history of children with severe combined immunodeficiency: The first fifty patients of the primary immune deficiency treatment consortium (PIDTC) prospective study 6901. J Clin Immunol. 33:1156-1164, 2013.
Kuehn HS, Niemela JE, Rangel-Santos A, Zhang M, Pitaluga S, Stoddard JL, Park L, Fleisher TA, Uzel G, Oliveira JB. Loss-of-function of the protein kinase C delta (PKCδ) causes a B cell lymphoproliferative syndrome in humans. Blood 121:3117-3125, 2013.
Snow A, Xiao W, Stinson J, Lu W, Chaigne-Delalande B, Zheng L, Pittaluga S, Mathews H, Schmitz R, Jhaver S, Kuchen S, Kardava L, Want W, Lamborn I, Jing H, Raffeld M, Moir S, Fleisher T, Staudt L, Su H, Lenardo M. Congenital B cell lymphocytosis explained by novel germline CARD11 mutations. J Exp Med, 209:2247-2261, 2012.