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Back to: Clinical Center Home Page > Departments and Services > Bench-to-Bedside Program > Previous Funded Awards > 2006 Bench-to-Bedside Awards and Funded Projects
Bench-to-Bedside Program
2006 Bench-to-Bedside Awards and Funded Projects

2006 Bench-to-Bedside Awards

NIH expands Initiative to Encourage Bench-to-Bedside Research

In 2006, the National Institutes of Health awarded nearly $4 million to fund 19 B2B medical research projects designed to speed translation of promising laboratory discoveries into new medical treatments. It was the first time applications for these awards, given since 1999, were open to research teams made up of NIH intramural and extramural collaborators from medical schools, health-care organizations and private industry. All but one of the funded projects include extramural partners; nine of the 19 projects involve researchers from two or more NIH institutes or centers.

The 2006 awards were made in four categories funded by the NIH Office of Rare Diseases; the NIH Office of AIDS Research; the National Center on Minority Health and Health disparities; and the NIH Office of Research on Women’s Health. A fifth category is co-funded by sponsoring institutes and, for the projects’ extramural components, the NIH National Center for Research Resources. Project teams receive up to $200,000 over two years to support their work.

Also in 2006, projects in minority health and health disparities and women’s health were specifically funded for the first time. Quality of the science, promise for becoming an active clinical trial, and potential for offering a new medical treatment or better understanding an important disease process were among selection criteria.

2006 Bench-to-Bedside Funded Projects



Institute or institution/Investigators

The effect of HIV-1 Infection on Endogenous miRNA Expression in vivo

NIAID: Jeang, Kuan-Teh St. Michael's Medical Center: Smith, Stephen

Genetic Characteristics of HIV-1 During Suppressive Antiretroviral Therapy

NCI: Maldarelli, Frank; Coffin, John; Palmer, Sarah; Weigand, Ann; Kearney, Mary Johns Hopkins University: Persaud, Deborah NIAID: Kottilil, Shyamasundaran

Evaluation of Molecular Methods for the non-invasive Diagnosis of Pneumocystis and Tuberculosis and Molecular Evaluation of Non-subtype B HIV Quasispecies in the Lung

CC: Kovacs, Joseph; Fischer, Steven NCI: Maldarelli, Frank University of California, San Francisco: Huang, Laurence San Francisco General Hospital: Davis, J. Lucian SAIC: Imamichi, Hiromi Makerere University, Mulago Hospital: Worodria, William; Yoo, Samuel

Microalbuminuria and Podocyturia in Patients with HIV disease: Detection, Characterization, and Therapy

NIDDK: Kopp, Jeffrey; Howard, Lilian Children's National Medical Center: McBryde, Kevin




Role of Cyclin D1 in Myelodysplasia

NHLBI: Sloand, Elaine; Young, Neal; Scheinberg, Phillip; Barrett, John CC: Kurlander, Roger Harvard University: Groopman, Jerome Georgetown University: Blancato, Jan National Naval Medical Center: More, Kenneth Salisbury District Hospital (UK): Crolla, John

Exploring the Anti-Tumor Effects of in vitro Expanded Natural Killer (NK) Cells Against Renal Cell Carcinoma Sensitized to NK-TRAIL Cytotoxicity with Bortezomib

NHLBI: Childs, Richard; Lundqvist, Andreas CC: Read, E.J.; Suffredini, Anthony Walter Reed Army Medical Center: Gorak, Edward; Alvarez, Gauri

A New Global Function for a Rare Disease Gene: Clinical Significance of the Regulation of Mitochondrial Respiration by Tumor Suppressor p53 in Li-Fraumeni Syndrome

NHLBI: Hwang, Paul
MD Anderson Cancer Center: Strong, Louise; Khakoo, Aarif; Arena, Ross

Therapeutic Approaches for Cancer Stem Cells in Small Cell Neuroendocrine Carcinomas

NCI: Harris, Curtis; Varticovski, Lyuba; Dennis, Phillip A.; Bates, Susan
NHLBI: Dunbar, Cynthia
NINDS: McKay, Ron Memorial Sloan-Kettering
Cancer Center: Travis, William D.

High Density Genotyping in Diffuse Large B-cell Lymphoma (DLBCL) and Follicular Lymphoma – Translating Etiologic Clues into Prognostic Relevance Within the NCI-SEER NHL Case Control Study

NCI: Chanock, Stephen; Wang, Sophia; Hartge, Patricia; Staudt, Lou; Morton, Lindsay; Wacholder, Sholom; Rothman, Nathaniel
Mayo Clinic College of Medicine: Cerhan, James
University of Southern California: Cozen, Wendy
Fred Hutchinson Cancer Research Center: Davis, Scott; Karmanos
Cancer Center & Wayne State University: Severson, Richard

Novel Suicide Gene-Modified Donor Th2 Cells for GVHD Prevention

CC: Reed, Elizabeth J.; Carter, Charles
NCI: Fowler, Daniel
University of Toronto/Ontario Cancer Institute: Medin, Jeffrey
University of Illinois: Lavie, Arnon

A Nutrigenomics Intervention for the Study of the Role of Dietary Sitosterol on Lipid, Glucose and Energy Metabolism

NIDDK: Celi, Francesco
NHLBI: Sachdev, Vandana
University of Maryland: Horenstein, Richard; Fried, Susan; Shuldiner, Alan

Pilot Trial of Intravenous Nitrite for Sickle Cell Vaso-Occlusive Pain Crisis

NHLBI: Gladwin, Mark; Machado, Roberto; Taylor, James; Wang, Xunde
CC: Kato, Gregory
NIDDK: Schechter, Alan; Shiva, Sruti
NCI: Mack, Kyle
Drexel University: Hsu, Lewis



Institute or institution/Investigators

Hemolysis, HIV/AIDS and Parasitic Infections Associated Secondary Pulmonary Arterial Hypertension in Sickle Cell Diseases

NHLBI: Aliyi, Zakari; Gladwin, Mark; Taylor, James, G.; Machado, Roberto
CC: Cato, Gregory 
: Rogers, Griffin

Novel Bench-to-Bedside Research Methods for Drug Addiction: Development, Validation and Application

NIDA: Stein, Elliott
University of Pennsylvania: Childress, Anna Rose; Peoples, Laura

Breast Cancer among African American Women: The role of Missense Changes in the BRCA1 and BRCA2 Breast Cancer Susceptibility Genes Using a Population-Based Approach

NHGRI: Ostrander, Elaine
Fred Hutchinson Cancer Research Institute: Malone, Kathleen

Melanocortin 3 receptor Mutations as an Etiology for Obesity in African American and Caucasian children

NICHD: Yanovski, Jack; Ning, Cong; Koo, Ja-Shin; Westphal, Heiner J.
NIDDK: Gavrilova,
Oksana University of Wisconsin: Schoeller, Dale



Institute or institution/Investigators

Vitamin E Pharmacokinetics and Oxidative Biomarkers in Normal and Obese Women

NIDDK: Levine, Mark
Oregon State University: Traber, Maret



Institute or institution/Investigators

Immunosuppression Minimization by Biological Response Monitoring

NIDDK: Kirk, Allen Washington
Hospital Center: Light, Jimmy

A Preliminary Assessment of the use of Ocular Coherence Tomography and Magnetic Resonance Imaging as Outcome Measures for Studying the Optic Nerve in Studies of Neuroprotection in Multiple Sclerosis

NINDS: McFarland, Henry
NEI: Nussenblatt, Robert
Johns Hopkins School of Medicine: Calabresi, Peter
University of Pennsylvania: Balcer, Laura

Previous Awards Funded

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999

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This page last updated on 06/03/2015

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