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Bench-to-Bedside Program
FY 2006 Bench-to-Bedside Awards and Funded Projects

2006 Bench-to-Bedside Awards

NIH expands Initiative to Encourage Bench-to-Bedside Research

In 2006, the National Institutes of Health awarded nearly $4 million to fund 19 B2B medical research projects designed to speed translation of promising laboratory discoveries into new medical treatments. It was the first time applications for these awards, given since 1999, were open to research teams made up of NIH intramural and extramural collaborators from medical schools, health-care organizations and private industry. All but one of the funded projects include extramural partners; nine of the 19 projects involve researchers from two or more NIH institutes or centers.

The 2006 awards were made in four categories funded by the NIH Office of Rare Diseases; the NIH Office of AIDS Research; the National Center on Minority Health and Health disparities; and the NIH Office of Research on Women’s Health. A fifth category is co-funded by sponsoring institutes and, for the projects’ extramural components, the NIH National Center for Research Resources. Project teams receive up to $200,000 over two years to support their work.

Also in 2006, projects in minority health and health disparities and women’s health were specifically funded for the first time. Quality of the science, promise for becoming an active clinical trial, and potential for offering a new medical treatment or better understanding an important disease process were among selection criteria.

2006 Bench-to-Bedside Funded Projects

RARE DISEASES CATEGORY:

Institute(s)

Project

Investigators

NHLBI
(NIH Clinical Center, Harvard, Georgetown, National Naval Medical Center)

"Role of Cyclin D1 in Myelodysplasia"

PI: Neal S. Young, MD, NHLBI
PI: Elaine M. Sloand, MD, NHLBI
AIs: Roger Kurlander, MD, NIH Clinical Center; Jerome J. Groopman, MD, Harvard University; Jan Blancato, PhD, Georgetown University; Kenneth More, MD, NNMC

NHLBI CC
Walter Reed Army Medical Center

"Exploring the Anti-Tumor Effects of in vitro Expanded Natural Killer (NK) Cells Against Renal Cell Carcinoma Sensitized to NK-TRAIL Cytotoxicity with Bortezomib"

PI: Richard W. Childs, MD, NHLBI
PI: Gauri Alvarez, DO., WRAMC
PI: Andreas E. Lundqvist, PhD, NHLBI
AIs: E.J. Read, MD, and Anthony Suffredini, MD, NIH Clinical Center; Edward Gorak, DO, WRAMC; Maria Berg, NHLBI; Ramaprasad Srinivasan, MD, PhD, and Shivani Srivasatava, MD, NCI

NHLBI
MD Anderson Cancer Center

"A New Global Function for a Rare Disease Gene: Clinical Significance of the Regulation of Mitochondrial Respiration by Tumor Suppressor p53 in Li-Fraumeni Syndrome"

PI: Paul M. Hwang, MD, PhD, NHLBI
PI: Lousie Strong, MD, MD Anderson Cancer Center
AIs: Ross Arena, PhD, Medical College of Virginia; Aarif Khakoo, MD Anderson Cancer Center; Robert Balaban, MD, Satoaki Matoba, Michael Sack, Myron Waclawiw, NHLBI; Oksana Gavrilova, NIDDK

NCI
NHLBI

"Therapeutic Approaches for Cancer Stem Cells in Small Cell Neuroendocrine Carcinomas"

PI: Curtis C. Harris, MD, NCI
AIs: Lyuba Varticovski, MD, Phillip A. Dennis, MD, Susan Bates, MD, NCI; Cynthia Dunbar, MD, NHLBI; Ron McKay, PhD, NINDS; William D. Travis, MD, Memorial Sloan-Kettering Cancer Center

NCI
(DCEG & CCR)

"High Density Genotyping in Diffuse Large B-cell Lymphoma (DLBCL) and Follicular Lymphoma – Translating Etiologic Clues into Prognostic Relevance Within the NCI-SEER NHL Case Control Study"

PI: Sophia S. Wang, PhD, NCI
PI: Stephen Chanock, MD, CCR, NCI
AIs: Patricia Hartge, Lou Staudr, Nathaniel Roghman, Lindsay Morton, Sholom Wacholder, NCI; Wendy Cozen, University of Southern California; Richard Severson, Karmanos Cancer Institute and Wayne State University; Scott Davis, Fred Hutchinson Cancer Research Center and the University of Washington; James R. Cerhan, Mayo Clinic College of Medicine

CC, NCI
Univ. of Toronto/ Ontario Cancer Institute

“Novel Suicide Gene-Modified Donor Th2 Cells for GVHD Prevention”

PI: Daniel H. Fowler, MD, NCI
PI: Jeffrey Medin, PhD, Ontario Cancer Institute and Univ of Toronto
AIs: E.J. Reed, NIH Clinical Center; Aron Lavie, Ph.D, University of Illinois at Chicago

NIDDK
NHLBI
University of Maryland

"A Nutrigenomics Intervention for the Study of the Role of Dietary Sitosterol on Lipid, Glucose and Energy Metabolism"

PI: Francesco S. Celi, MD, NIDDK
AIs: Vandana Sachdev, MD, NHLBI; Alan Shuldiner, MD, Richard Horenstein, MD, JD, Susan K. Fried, PhD, University of Maryland, Division of endocrinology, Diabetes and Nutrition

NHLBI
CC

"Pilot Trial of Intravenous Nitrite for Sickle Cell Vaso-Occlusive Pain Crisis"

PI: Mark Gladwin, MD, NHLBI
PI: Gregory Kato, MD, CC
AIs: Lewis Hsu, MD, Drexel University and NIH Clinical Center; Kyle Mack, MD, NCI; Roberto Machado, MD, Sruti Shiva, PhD, James Taylor, MD, Xunde Wang, MD, NHLBI; Alan Schechter, MD, NIDDK

AIDS CATEGORY:

Institute(s)

Project

Investigators

NIAID
St. Michael’s Medical Center

“The effect of HIV-1 Infection on Endogenous miRNA Expression in vivo

PI: Kuan-Teh Jeang, MD, PhD, NIAID
AI: Stephen M. Smith, MD, St. Michaels’ Medical Center, NJ

NCI
Johns Hopkins University
NIAID

"Genetic Characteristics of HIV-1 During Suppressive Antiretroviral Therapy"

PI: Frank Maldarelli, MD, PhD, NCI
PI: Deborah Persaud, MD, Johns Hopkins School of Medine
AIs: John M. Coffin, PhD, Sarah Palmer, PhD, Ann Wiegand, MS, Mary Kearney, MS, NCI; Shyamasundaran Kottilil, MD, PhD, NIAID

CC
San Francisco General Hospital

Science Applications International Corporation (SAIC)

"Evaluation of Molecular Methods for the non-invasive Diagnosis of Pneumocystis and Tuberculosis and Molecular Evaluation of Non-subtype B HIV Quasispecies in the Lung"

PI: Joseph Kovacs, MD, CC
PI: Laurence Huang, MD, MAS, SFGH, UCSF
AIs: Steven Fischer, MD, CC; Frank Maldarelli, MD, NCI; Hiromi Imamichi, PhD, SAIC-Frederick; J. Lucian Davis, M.D., SFGH/UCSF; William Worodria, MBChB, MMed and Samuel Yoo, MD, Makerere University, Mulago Hospital

NIDDK
Children’s National Medical Center

"Microalbuminuria and Podocyturia in Patients with HIV disease: Detection, Characterization, and Therapy"

PI: Jeffrey Kopp, MD, NIDDK
PI: Kevin D. McBryde, MD, Dept of Pediatrics, Children’s National Medical Center

MINORITY HEALTH AND HEALTH DISPARITIES:

Institute(s)

Project

Investigators

NHLBI
CC

"Hemolysis, HIV/AIDS and Parasitic Infections Associated Secondary Pulmonary Arterial Hypertension in Sickle Cell Diseases"

PI: Mark Gladwin, MD, NHLBI
PI: Zakari Y. Aliyi, MD, NHLBI
AI: Griffin Rogers, MD, NIDDK; James G. Taylor, MD, and Roberto Machado, MD, NHLBI; Gregory Kato, NIH CC/CCMD

NIDA
University of Pennsylvania

"Novel Bench-to-Bedside Research Methods for Drug Addiction: Development, Validation and Application"

PI: Laura L. Peoples, PhD, University of Pennsylvania
PI: Elliot.Stein, PhD, NIDA
AI: Anna Rose Childress, PhD, University of Pennsylvania

NHGRI
Fred Hutchinson Cancer Research Center

"Breast Cancer among African American Women: The role of Missense Changes in the BRCA1 and BRCA2 Breast Cancer Susceptibility Genes Using a Population-Based Approach"

PI: Elaine Ostrander, PhD, NHGRI
AI: Kathleen E. Malone, PhD, Fred Hutchinson Cancer Research Center, Seattle

NICHD
NIDDK
University of Wisconsin

"Melanocortin 3 receptor Mutations as an Etiology for Obesity in African American and Caucasian children"

PI: Jack A. Yanovski, MD, PhD, NICHD
PI: Dale A. Schoeller, PhD, University of Wisconsin
AI: Oksana Gavrilova, PhD, NIDDK; Cong Ning, MD, PhD, Ja-Shin Koo, PhD, Heiner J. Westphal, MD, NICHD

WOMEN’S HEALTH

Institute(s)

Project

Investigators

NIDDK
Oregon State University

"Vitamin E Pharmacokinetics and Oxidative Biomarkers in Normal and Obese Women"

PI: Mark A. Levine, MD, NIDDK
PI: Maret G. Traber, PhD, Oregon State University

CO-FUNDED (INSTITUTE AND NCRR)

Institute(s)

Project

Investigators

NIDDK
Washington Hospital Center

"Immunosuppression Minimization by Biological Response Monitoring"

PI: Allan D. Kirk, MD, NIDDK
AI: Jimmy Light, MD, Washington Hospital Center

NINDS NEI
Johns Hopkins School of Medicine
University of Pennsylvania

"A Preliminary Assessment of the use of Ocular Coherence Tomography and Magnetic Resonance Imaging as Outcome Measures for Studying the Optic Nerve in Studies of Neuroprotection in Multiple Sclerosis" project to evaluate

PI: Henry McFarland, MD, NINDS
PI: Robert Nussenblatt, MD, NEI
PI: Peter A. Calabresi, MD, Johns Hopkins School of Medicine
PI: Laura J. Balcer, MD, University of Pennsylvania

Previous Awards Funded

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999


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This page last reviewed on 01/30/14



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