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Bench-to-Bedside Program
NIH Bench-to-Bedside Program

NIH Clinical Center Bench-to-Bedside Program Slideshow

Text version of the slideshow

The Bench-to-Bedside (B2B) Program funds research teams seeking to translate basic scientific findings into therapeutic interventions for patients and to increase understanding of important disease processes.

The B2B Program accomplishes this mission by addressing barriers, such as the traditional silos between basic and clinical researchers in biomedical research, which can hinder progress toward finding new therapeutics for patients in need. B2B teams involve basic and clinical researchers, often from different NIH Institutes and Centers. In 2006, the B2B program's charge was expanded to unite the efforts of intramural and extramural NIH researchers. Intramural science refers to research that takes place on an NIH campus under the auspices of federal employees, while extramural research is funded by NIH and conducted by investigators and institutions outside of NIH.

The B2B program exemplifies the benefits associated with intramural – extramural collaborations; the extramural community gains access to the Clinical Center's unique resources, and the intramural community can pursue innovative research with extramural investigators.

A B2B award provides up to $135,000 a year for two years. Projects, which are funded by various NIH offices and institutes*, have represented several research categories: AIDS, rare diseases, behavioral and social sciences, minority health and health disparities, women's health, rare diseases drug development, pharmacogenomics, and general.

Through the end of the 2013 program cycle, about 700 principal and associate investigators have collaborated on 219 funded projects with approximately $50M distributed in total bench-to-bedside funding. The introduction of extramural collaborations in 2006 has resulted in partnerships at 79 institutions, 30 of which are Clinical and Translational Science Award sites.

The B2B program is now accepting letters of intent for the next cycle of awards. The timeline for the application cycle is below. For more information, please see Information for Applicants.

Milestone Date

Letter of Intent due date

June 18, 2014

Notification of invitation to submit full proposal

July 9, 2014

Application due date

August 20, 2014

Applications reviewed

November 2014

Investigators notified of funding decisions

December 2014

Earliest start date

January/February 2015



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This page last reviewed on 05/15/14



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