NIH Clinical Center: Schedule/Syllabus

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Principles of Clinical Pharmacology: Schedule/Syllabus

2008-2009 Course Schedule

All sessions will meet Thursday evenings from 6:30 p.m. to approximately 7:45 p.m. Eastern time in the NIH Clinical Center, Building 10, in the Lipsett Amphitheater in Bethesda, Maryland.

If you experience any accessibility problems with the PDFs below, please contact (301) 496-9425 or email CC-OD_Clinp@mail.cc.nih.gov

September 4	Introduction to course Slides of Introduction to course from previous year lecture Video of Introduction to course from previous year lecture with caption	J. Lertora
MODULE 1: PHARMACOKINETICS
September 11	Clinical pharmacokinetics Slides of Clinical pharmacokinetics from previous year lecture Video of Clinical pharmacokinetics from previous year lecture with caption	J. Lertora
September 18	Chemical assay of drugs and drug metabolites Slides of Chemical assay of drugs and drug metabolites from previous year lecture Video of Chemical assay of drugs and drug metabolites from previous year lecture with caption	S. Markey
September 25	Compartmental analysis of drug distribution Slides of Compartmental analysis of drug distribution from previous year lecture Video of compartmental analysis of drug distribution from previous year lecture with caption	J. Lertora
October 2	Drug Absorption and bioavailability Slides of Drug Absorption and Bioavailability from previous year lecture Video of drug absorption and bioavailability from previous year lecture with caption	J. Lertora
October 9	Use of positron emission tomography (PET) in pharmacokinetics Slides of Use of positron emission tomography (PET) in pharmacokinetics slides from previous year lecture Video of Positron emission tomography (PET) from previous year lecture with caption PET from previous year Lecture -Video 1 PET from previous year Lecture -Video 2	R. Innis
October 16	Effects of renal disease on pharmacokinetics Journal article in Seminars in Dialysis – Vol 16, No 1 (January-February) 2003 pp 45-50. Article entitled, The Effect of Chronic Renal Failure on Hepatic Drug Metabolism and Drug Disposition, authors Albert W. Dreisbach and Juan J.L. Lertora. Slides of Effects of Renal Disease on Pharmacokinetics from previous year lecture Video of Effects of Renal Disease on Pharmacokinetics from previous year lecture with caption	J. Lertora
October 23	SPECIAL LECTURE: Pharmacokinetics in patients requiring renal replacement therapy Slides of pharmacokinetics in patients requiring renal replacement from previous year (Dr. Atkinson's slides) Slides of pharmacokinetics in patients requiring renal replacement from previous year (Dr. Susla's slides) Video of pharmacokinetics in patients requiring hemodialysis from previous year lecture Video with caption Supplemental Reading: FDA Guidance for Industry: Pharmacokinetics in Patients with Impaired Renal Function – Study Design, Data Analysis, and Impact on Dosing and Labeling. http://www.fda.gov/cder/guidance/1449fnl.pdf	A. Atkinson/G. Susla
October 30	Noncompartmental vs. compartmental approaches to PK analysis Slides of noncompartmental vs. compartmental approaches to PK data analysis from previous year lecture Video of noncompartmental vs. compartmental approaches to PK data analysis from previous video with caption	P. Vicini
November 6	Effects of liver disease on pharmacokinetics Slides of effects of liver disease on pharmacokinetics from previous year lecture Supplemental Reading: FDA Guidance for Industry: Pharmacokinetics in Patients with Impaired Hepatic Function: Study Design, Data Analysis, and Impact on Dosing and Labeling. http://www.fda.gov/cber/gdlns/imphep.pdf Video of effects of liver disease on pharmacokinetics from previous year lecture video with caption	J. Lertora
November 13	Population pharmacokinetics Slides of population pharmacokinetics from previous year lecture Video of population pharmacokinetics from previous year video with caption	R. Miller
MODULE 2: DRUG METABOLISM AND TRANSPORT
November 20	Pathways of drug metabolism Slides of pathways of drug metabolism from previous year lecture Video of pathways of drug metabolism from previous year lecture video with caption	S. Markey
December 4	Pharmacogenetics Slides of pharmacogenetics from previous year lecture Video of pharmacogenetics from previous year lecture video with caption	D. Flockhart
December 11	Drug Interactions Slides of drug interactions from previous year lecture Video of drug interactions from previous year lecture video with caption	S. Penzak
December 18	Biochemical mechanisms of drug toxicity Slides of Biochemical mechanisms of drug toxicity from previous year lecture Video of Biochemical mechanisms of drug toxicity from previous year lecture video with caption	L. Pohl
January 8	Equilibrative and concentrative transport Slides of Equilibrative and concentrative transport from previous year lecture Video of Equilibrative and concentrative transport from previous year lecture video with caption	J. Ware
January 15	SPECIAL LECTURE: P-glycoprotein and drug transport Dr. Innis's slides from previous year lecture Dr. Gottesman's slides from previous year lecture Journal Article provided by Dr. Innis Video of P-glycoprotein and drug transport from previous year lecture video with caption	M. Gottesman R. Innis
MODULE 3: ASSESSMENT OF DRUG EFFECTS:
January 22	Dose response and concentration response analysis Slides of Dose response and concentration response analysis from previous year lecture Video of Dose response and concentration response analysis from previous year lecture video with caption	F. Balis
January 29	Physiological and laboratory markers of drug effect Slides of physiological and laboratory markers of drug effect from previous year lecture Video of physiological and laboratory markers of drug effect from previous year lecture video with caption	J. Woodcock
February 5	Disease progression models and clinical trial simulation Slides of disease progression models and clinical trial simulation from previous year lecture Video of disease progression models and clinical trial simulation from previous year lecture	D. Mould
MODULE 4: Optimizing and Evaluating Patient Therapy
February 12	Drug therapy in pregnant and nursing women Slides of drug therapy in pregnant and nursing women from previous year lecture Video of drug therapy in pregnant and nursing women from previous year lecture	M. Frederiksen
February 19	Developmental and pediatric pharmacology Slides of developmental and pediatric pharmacology from previous year lecture Video of developmental and pediatric pharmacology previous year lecture video with caption	F. Balis
February 26	Drug therapy in the elderly Slides of drug therapy in the elderly previous year lecture Video of dr

MODULE 1: PHARMACOKINETICS

MODULE 2: DRUG METABOLISM AND TRANSPORT

MODULE 3: ASSESSMENT OF DRUG EFFECTS:

MODULE 4: Optimizing and Evaluating Patient Therapy