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Dr. Andrew Mannes, MD, ME

Andrew Mannes, MD, ME
Department of Perioperative Medicine

Academic Degrees
BS, University of Pennsylvania
ME, Dartmouth College
MD, George Washington University


Phone: 301-594-3427

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NIH Clinical Center Senior Staff

Andrew Mannes, MD, ME


Dr. Andrew Mannes is chief of the Clinical Center's Department of Perioperative Medicine. Dr. Mannes has a long-standing interest in the treatment of severe pain often seen at the end of life. His current interests include developing pain therapies using gene therapy; targeting pain pathways with selective agonists, toxins, or fusion proteins; and improving the diagnosis of disease states using proteomic and genomic techniques.

Dr. Mannes has written widely in books and medical journals on such topics as advances in cancer pain management, gene therapy for pain, and neurosurgical intervention approaches to pain relief. He is board certified in anesthesiology and fellowship-trained in pain management. He collaborates with the Clinical Center's Pain and Palliative Care Service in the area of pain management and has also worked on treatment of chronic pain with investigators in the laboratories of the Pain and Neurosensory Mechanisms Branch of the National Institute of Dental and Craniofacial Research.

Following completion of a Bachelor of Science degree in Bio-Engineering at the University of Pennsylvania and a Master of Engineering degree at Dartmouth College, Dr. Mannes received his MD degree at George Washington University. He completed a transitional internship at the Presbyterian Hospital of Philadelphia followed by an anesthesia residency at the Hospital of the University of Pennsylvania. While at University of Pennsylvania, he completed a fellowship in pain management and joined the Penn faculty as an Instructor in Anesthesiology in 1994. He was promoted to Assistant Professor of Anesthesiology in 1997 before coming to NIH. Dr. Mannes completed an NIH research fellowship in molecular biology in 1997. He has been in the Department of Anesthesia and Surgical Services since 2001.

Dr. Mannes is a member of the American Medical Association and is on the editorial advisory board of Open Pain Journal.

Selected Honors and Awards

In 2009, Dr. Mannes received the National Institutes of Health Director's Award for his work on advancing resiniferatoxin to a successful IND approval, enabling its evaluation in clinical trials as a treatment for intractable pain. 1981 Hexagon Society (University of Pennsylvania).

Selected Publications

Book Chapters

Yeoman D, Mannes AJ, Saitoh Y. Gene therapy for pain: Different approaches toward a common goal. In: Proceeding of the World Congress on Pain. 2003. IASP Press Seattle, WA.

Mannes AJ, Tobias MD, Lonser R. Neurosurgical and Interventional Approaches in Cancer Pain Management. In: Advances in Cancer Pain. Oncology Group, CMP Communications. 2004.

Mannes AJ, Kim PS, Lonser R. Neurosurgical Interventional Approaches to Pain in the 3rd edition of Principles and Practice of Palliative Care and Supportive Care. 2005.

Mannes AJ, Kim PS, Lonser R. Neurosurgical Interventional Approaches to Pain in the 4th edition of Principles and Practice of Palliative Care and Supportive Care. 2012.

Iadarola MJ, Lee S, Mannes AJ: Gene transfer approaches to pain control. In: Molecular Neurobiology of Pain. D. Borsook (Ed.) Progress in Pain Research and Management 9:337-359, 1997. IASP Press Seattle, WA.

Journal Articles

Caudle RM, Mannes AJ, Iadarola MJ. Activation of spinal kappa2 opioid receptors. Emerging Therapeutic Targets 1:109-112, 1997.

Mannes AJ, Caudle RM, O'Connell B, Iadarola MJ. Adenoviral Transfer of LacZ to Spinal Cord Neurons. Brain Research 793:1-6, 1998.

Caudle RM, Mannes AJ: Dynorphin: Friend or foe? Pain 87:(3)235-239, 2000.

Ferrante FM, King LF, Roche EA, Kim PS, Aranda M, DeLaney LR, Mardini IA, Mannes AJ: Radiofrequency sacroiliac joint denervation for sacroiliac syndrome. Reg Anesth Pain Med 26:137-142, 2001.

Polomano RC, Mannes AJ, Clark US and Bennett GJ. A Painful Peripheral Neuropathy in the Rat Produced by the Chemotherapeutic Drug, Paclitaxel. Pain 94(3) 293-304, 2001

Mannes AJ, Martin B, Yang HY, Keller J, Lewin S, Gaiser R, Iadarola MJ. Cystatin C as a Cerebrospinal Fluid Biomarker for Pain in Humans. Pain 102(3) 251-6, 2003

Brown, DC, Iadarola MJ, Perkowski SZ, Hardam ED, Shofer F, Karai L, Olah, Z, Mannes, AJ. Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiology. 103(5) 1052-1059. 2005.

Mannes AJ, Brown DC, Keller J, Caudle RM, Cordes, Lauren L, Iadarola MJ, Meng QC. Measurement of Resiniferatoxin in Serum by High-performance Liquid Chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 823 (2) 184-8. 2005.

Mannes AJ, Grippo RJ, Chang R, Wood Bradford J. Case Study: Percutaneous Vertebroplasty as a Palliative Measure in Setting of Chronic Infection. J. Pain Sympt. (5):382-4 2006.

Mannes AJ, Iadarola MJ. Potential downsides of perfect pain relief. Nature vol. 446: 24, 2007.

Mannes AJ, Iadarola MJ. Complete pain relief: potential problems and diagnostic solutions. Nature Clin Pract Neurol. 3 (12): 648-649 2007.

Mannes AJ, Shepherd M, Quezado Z. Resolution of diplopia with late treatment of post-dural puncture headache and intracranial hypotension. Can J Anes 2008.

Stewart D, Lee, Mannes, Moshyedi, Sloan, Yao, Legius. Diagnosis, management, and complications of glomus tumors of the fingers in neurofibromatosis type 1. J Med Genet 47:8 525-32 2010.

Bates, B, Mitchell K, Keller JM, Chan CC, Swaim WD, Yanskovich R, Mannes AJ, Iadarola MJ. Prolonged analgesic response of cornea to topical resiniferatoxin, a potent TRPV1 agonist Pain 149(3) 522-528 2010.

Guptill V, Cui X, Uehara Y, Horowitz, J, Middleton L, Khaibullina A, Mannes A, Iadarola M, and Quezado Z. Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis. Anesthesiology, 114 (5) pp. 1190-1199 2011.

Iadarola MJ, Mannes AJ: The Vanilloid Agonist Resiniferatoxin for Interventional-Based Pain Control. Current Topics in Drug Development, 1-9. 2011.

Soto E, Stewart DR, Mannes AJ, Ruppert SL, Baker K, Zlott D, Handel D, Berger AM. Oral Ketamine in the Palliative Care Setting: A Review of the Literature and Case Report of a Patient With Neurofibromatosis Type 1 and Glomus Tumor-Associated Complex Regional Pain Syndrome. Am J Hosp Palliat Care 2011.

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This page last updated on 07/06/2017

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