Bradford Wood, MD

Bradford Wood, MD
Director
NIH Center for Interventional Oncology
Chief
Interventional Radiology Section

Academic Degrees
BA, University of Virginia
MD, University of Virginia

Email: bwood@nih.gov

Phone: 301-443-8191

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NIH Clinical Center Senior Staff

Bradford Wood, MD

Biosketch

Dr. Bradford Wood directs a multi-disciplinary team (NIH Center for Interventional Oncology) that develops and translates devices, software, and navigation approaches for cancer patients via novel local and regional minimally-invasive image-guided therapies. Dr. Wood earned both undergraduate and graduate degrees from The University of Virginia, did Internal Medicine internship, followed by Residency in Diagnostic Radiology at Georgetown University, where he was Chief Resident. He then went on to do double fellowships at Harvard / Massachusetts General Hospital in Abdominal Imaging and Intervention and Vascular & Interventional Radiology, and stayed on staff at MGH after training.

Dr. Wood came to the NIH in 1998, and has directed the Interventional Radiology Research Lab from 2004 to present, and was Acting Co-Director of Radiology from 2006 to 2008. His research relies upon multi-disciplinary team science within multiple institutes and holds appointment in Radiology & Imaging Sciences in the CC, as well as the Urological Oncology Branch in NCI/CCR. He has received both the Clinical Center Director’s Award and the NIH Director’s Award, and has published widely in the field of Interventional Radiology and the emerging discipline in Interventional Oncology.

The Center for Interventional Oncology translates technologies and paradigms for first in human treatments for cancer and cultivates interventional radiology applications within a muliti-disciplinary framework, to apply biomedical engineering to solve real-life clinical problems and patient care needs.

His team’s achievements include helping to pioneer several technologies from concept to bench to patient, including prostate cancer MRI/TRUS fusion biopsy and ablation, image-able iodinated drug eluting beads for chemoembolization of liver tumors, heat deployed chemotherapy combined with thermal ablation for liver cancer, “medical GPS” electromagnetic (EM) tracking for fusion of ultrasound to CT, MR, and PET, and fusion for needle-based procedures like biopsy and thermal ablation, and other smart needles, devices, and software for minimally invasive, multi-modality, image-guided procedures. The NIH team has performed over 30,000 needle procedures in over 2,000 patients with this tracking and fusion technology, which has become standard of care in many community settings. Dr. Wood &/or the CIO team performed "First-in-human" treatments including: First radiofrequency ablation (RFA) for kidney tumors; First RFA of pheochromocytoma, lymphoma, adrenocortical carcinoma, liver abscess, chordoma, and intractable hematuria; First thermal ablation of liver tumors augmented with heat-deployed liposomal doxorubicin; First iodinated & image-able drug eluting bead embolization of liver tumors; First GPS-enabled ablation and biopsy devices; Ultrasound fusion enabled navigation systems;  and PET, MRI, CT and ultrasound fusion interventions.

Selected Publications

Dr. Wood has published extensively in the field, co-authoring books on radiology, Interventional Urology, many patents and over 350 manuscripts, with recent papers in JAMA, Lancet, and Science.

Siddiqui MM, Rais-Bahrami S, Turkbey B, George A, Rothwax J, Shakir N, Okoro C, Raskolnikov D, Parnes HL, Linehan WM, Merino MJ, Simon RM, Choyke PL, Wood BJ, Pinto PA: Comparison of MR/Ultrasound Fusion-Guided Biopsy With Ultrasound-Guided Biopsy for the Diagnosis of Prostate Cancer. JAMA 2015, Jan 27;313(4):390-397

Levy EB, Krishnasamy VP, Lewis AL, Willis S, Macfarlane C, Anderson V, van der Bom IM, Radaelli A, Dreher MR, Sharma KV, Negussie A, Mikhail AS, Geschwind JF, Wood BJ: First Human Experience with Directly Image-able Iodinated Embolization Microbeads. Cardiovasc Intervent Radiol. 2016 Aug;39(8):1177-86
Lewis AL, Dreher MR, O'Byrne V, Grey D, Caine M, Dunn A, Tang Y, Hall B, Fowers KD, Johnson CG, Sharma KV, Wood BJ: DC BeadM1™: towards an optimal transcatheter hepatic tumour therapy. J Mater Sci Mater Med. 2016 Jan;27(1):13

Johnson CG, Sharma KV, Levy EB, Woods DL, Morris AH, Bacher JD, Lewis AL, Wood BJ, Dreher MR: Microvascular Perfusion Changes following Transarterial Hepatic Tumor Embolization. J Vasc Interv Radiol. 2016 Jan;27(1):133-141

Abi-Jaoudeh N, Fisher T, Jacobus J, Skopec M, Radaelli A, Van Der Bom IM, Wesley R, Wood BJ: Prospective Randomized Trial for Image-Guided Biopsy Using Cone-Beam CT Navigation Compared with Conventional CT.  J Vasc Interv Radiol 2016 Sep;27(9):1342-9

Levy EB, Gacchina Johnson C, Jacobs G, Woods DL, Sharma KV, Bacher JD, Lewis AL, Dreher MR, Wood BJ: Direct Quantification and Comparison of Intratumoral Hypoxia following Transcatheter Arterial Embolization of VX2 Liver Tumors with Different Diameter Microspheres. J Vasc Interv Radiol. 2015 Oct;26(10):1567-7

Levy EB, Gacchina Johnson C, Jacobs G, Woods DL, Sharma KV, Bacher JD, Lewis AL, Dreher MR, Wood BJ: Direct Quantification and Comparison of Intratumoral Hypoxia following Transcatheter Arterial Embolization of VX2 Liver Tumors with Different Diameter Microspheres. J Vasc Interv Radiol. 2015 Oct;26(10):1567-7

Turkbey B, Brown AM, Sankineni S, Wood BJ, Pinto PA, Choyke PL: Multiparametric prostate magnetic resonance imaging in the evaluation of prostate cancer. CA Cancer J Clin. 2015

Abi-Jaoudeh N, Duffy AG, Greten TF, Kohn EC, Clark TW, Wood BJ: . Personalized oncology in interventional radiology. J Vasc Interv Radiol. 2013 Aug;24(8):1083-92

Amalou H, Wood BJ: Biopsy and personalized medicine. Nature Rev Gastroenterol Hepatol. 2012 Nov;9(11):683

Venkatesan AM, Kadoury S, Abi-Jaoudeh N, Levy EB, Maass-Moreno R, Krücker J, Dalal S, Xu S, Glossop N, Wood BJ: Real-time FDG PET Guidance during Biopsies and Radiofrequency Ablation Using Multimodality Fusion with Electromagnetic Navigation. Radiology. 2011 Sep;260(3):848-56

Krücker J, Xu S, Venkatesan A, Locklin J, Amalou H, Glossop N, Wood BJ: Clinical Utility of Real-Time Fusion Guidance for Biopsy and Ablation. J Vasc Interv Radiol  2011;22:515-24

Pinto PA, Chung PH, Rastinehad AR, Baccala AA Jr, Kruecker J, Benjamin CJ, Xu S, Yan P, Kadoury S, Chua C, Locklin JK, Turkbey B, Shih JH, Gates SP, Buckner C, Bratslavsky G, Linehan WM, Glossop ND, Choyke PL, Wood BJ:  Magnetic resonance imaging/ultrasound fusion guided prostate biopsy improves cancer detection following transrectal ultrasound biopsy and correlates with multiparametric magnetic resonance imaging. J Urol. 2011 Oct;186(4):1281-5

Xu S, Kruecker J, Guion P, Glossop N, Neeman Z, Choyke P, Singh AK, Wood BJ: Closed-loop control in fused MR-TRUS image-guided prostate biopsy. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2007;10:128-35

Krücker J, Xu S, Glossop N, Viswanathan A, Borgert J, Schulz H, Wood BJ: Electromagnetic tracking for thermal ablation and biopsy guidance: clinical evaluation of spatial accuracy. J Vasc Interv Radiol 2007;18:1141-1150

Dromi SA, Herby S, Walsh M, Dreher M, Xie J, Fry T, Wood BJ: Radiofrequency Ablation Induces Antigen Presenting Cell Infiltration and Amplification of Weak Tumor-Induced Immunity, Radiology 2009; 251:58-66

Sharma KV, Dreher MR, Tang Y, Pritchard W, Chiesa OA, Karanian J, Perogoy J, Orandi B, Woods D, Donahue D, Esparza J, Jones G, Willis SL, Lewis AL, Wood B: Development of "imageable" beads for transcatheter embolotherapy., J Vasc Interv Radiol 2010;21:865-76

Dreher MR, Sharma KV, Woods DL, Reddy G, Tang Y, Pritchard WF, Chiesa OA, Karanian JW, Esparza JA, Donahue D, Levy EB, Willis SL, Lewis AL, Wood BJ: Radiopaque Drug-Eluting Beads for Transcatheter Embolotherapy: Experimental Study of Drug Penetration and Coverage in Swine. J Vasc Interv Radiol. 2012 Feb;23(2):257-64

McGovern FJ, Wood BJ, Goldberg SN, Mueller PR: Radiofrequency Ablation of Renal Cell Carcinoma via Image Guided Needle Electrodes. J Urology 1999;161: 599-600

Wood BJ, Ramkaransingh JR, Fojo T, Walther MM, Libutti SK: Percutaneous Tumor Ablation with Radiofrequency. Cancer 2002; 94:443-451
Pacek K, Fojo T, Goldstein DS, Eisenhofer G, Walther M, Linehan WM, Bachenheimer L, Abraham J, Wood BJ: Radiofrequency Ablation (RFA): A novel approach for the treatment of metastatic pheochromocytoma. J Natl Cancer Inst 2001;93:648-649

Dromi S, Frenkel V, Luk A, Traughber B, Angstadt M, Bur M, Poff J, Xie J, Libutti SK, Li KCP, Wood BJ: Pulsed-high intensity focused ultrasound and low temperature sensitive liposomes for enhanced targeted drug delivery and anti-tumor effect. Clin Cancer Res 2007;13:2722-2727

Wood BJ, Poon RT, Locklin J, Dreher MR, Ng KK, Eugeni M, Seidel G, Dromi S, Neeman Z, Kolf M, Black CDV, Prabhakar R, Libutti SK: A Phase I Study of Heat Deployed Liposomal Doxorubicin during Radiofrequency Ablation for Hepatic Malignancies. J Vasc Interv Radiol 2012

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