Holland presents 2022 Astute Clinician Lecture
Addresses role of anticytokine autoantibodies
Dr. Steven Holland gave the Astute Clinician Lecture as a part of the NIH Director's Wednesday Afternoon Lecture Series on November 2 by NIH Videocast. He presented "Anticytokine Autoantibodies: Causes, Concomitants and Complications of Infectious Diseases." Holland's lecture marked the 25th anniversary milestone for the Astute Clinician Lecture Series.
Holland is an NIH Distinguished Investigator, NIAID Scientific Director and Chief of the Immunopathogenesis Section. The Section uses a bench-to-bedside model for a fully integrated approach to infectious disease – incorporating the molecular genetics of the host and the pathogen as well as mechanisms of pathogenesis, together with clinical appreciation and investigation – to gain new insights into both mechanisms of action and avenues of therapy.
Holland earned his MD from Johns Hopkins University where he remained for his internal medicine residency, chief residency and fellowship in infectious diseases. He came to NIAID as a National Research Council fellow in 1989 with the Laboratory of Molecular Microbiology, working on transcriptional regulation of HIV. In 1992, he joined the newly formed Laboratory of Host Defenses, shifting his research to the host side, with a focus on phagocyte defects and their associated infections. His work centered on the pathogenesis and management of chronic granulomatous disease, as well as other congenital immune defects affecting phagocytes, including those predisposing to mycobacterial diseases. Holland became Scientific Director for NIAID's Division of Intramural Research in 2016.
The Astute Clinician Lecture was established in 1998 through a gift from the late Dr. Robert W. Miller and his wife, Haruko. The lecture honors U.S. scientists who have observed unusual clinical occurrences and, by investigating them, have opened an important new avenue of research. Learn more.