Bench-to-Bedside Program

NIH Bench-to-Bedside Program

The 2017 Bench-to-Bedside Cycle is now underway! LOIs are due July 14. An information session for interested applicants was held recently; for a link to the archived session, please contact Julie Orlando at julie.orlando@nih.gov.

The Bench-to-Bedside (BtB) Program funds research teams seeking to translate basic scientific findings into therapeutic interventions for patients and to increase understanding of important disease processes.

The BtB Program accomplishes this mission by addressing barriers, such as the traditional silos between basic and clinical researchers in biomedical research, which can hinder progress toward finding new therapeutics for patients in need.

BtB teams involve basic and clinical researchers, often from different NIH Institutes and Centers. In 2006, the BtB program's charge was expanded to unite the efforts of intramural and extramural NIH researchers. Intramural science refers to research that takes place on an NIH campus under the auspices of federal employees, while extramural research is funded by NIH and conducted by investigators and institutions outside of NIH.

The BtB program exemplifies the benefits associated with intramural – extramural collaborations; the extramural community gains access to the Clinical Center's unique resources, and the intramural community can pursue innovative research with extramural investigators.

Each BtB award provides up to $150,000 a year for two years. Projects, which are funded by various NIH offices and institutes*, have represented several research categories: AIDS, rare diseases, behavioral and social sciences, minority health and health disparities, women's health, rare diseases drug development, pharmacogenomics, and general.

To date, approximately 800 principal and associate investigators have collaborated on 238 funded projects with approximately $53 million distributed in total Bench-to-Bedside funding. The introduction of extramural collaborations in 2006 has resulted in 157 partnerships at 90 institutions. Ninety-seven percent of of BtB awards spanning the three most recent review cycles have involved extramural partners.

Bench to Bedside Report pdf icon (1.45 MB)
An in-depth review of the BtB Program was completed in August 2014 and updated in September 2016. The report includes important historical data, program trends, and funding information gathered since BtB was expanded to foster collaborations between intramural and extramural investigators eight years ago.

Text version of the slideshow:

  • Slide 1 - Bench-to-Bedside
  • Slide 2 - Dr. Frank Maldarelli discusses "New Bioinformatic Approach to Determing HIV Incidence"
  • Slide 3 - Dr. Manfred Boehm discusses "Aneurysm Formation in Patients with Mutation of STAT3"
  • Slide 4 - Dr. Jack Yanovski discusses "FTO and Eating in the Absence of Hunger"
  • Slide 5 - Dr. Joan Han discusses "WAGR Syndrome: Clinical Characterization and Correlation with Genotype"
  • Slide 6 - Dr. Michael Iadarola discusses "New Treatments for Intractable Pain"

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This page last updated on 06/30/2017

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