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Bench-to-Bedside Program

About Bench-to-Bedside

The NIH Bench-to-Bedside program, originally established in 1999 to integrate the work of basic and clinical intramural scientists and since 2006 open to partnerships between intramural and extramural programs, is soliciting proposals for the next cycle of funding. (Intramural science refers to research that takes place on an NIH campus under the auspices of federal employees, while extramural research is conducted by investigators and institutions outside of NIH.) Once again, CTSA, AIAMC (Alliance for Independent Academic Medical Centers), and NIH investigators will be able to initiate applications jointly for Bench-to-Bedside research projects. Up to $150K per year for two years is available to support these intramural/extramural partnerships in clinical research. Projects can involve only intramural investigators, but collaborations between intramural and extramural investigators will receive priority review.

As in prior years, intramural investigators in all institutes/centers are eligible to serve as project leaders on proposals. Extramural principal investigators (PIs) with an existing NIH grant (e.g., researchers at CTSA or AIAMC sites) are invited to initiate proposals in one of two ways. First, extramural investigators may seek an intramural partner at NIH who would function as the project leader and serve as the point of contact. To identify an intramural collaborator, extramural investigators can consult the NIH's database of all current intramural research at Bench to Bedside program staff are also able to assist in identifying intramural partners.

Second, extramural investigators may initiate proposals and serve as project leaders. In this role, extramural principal investigators will develop letters of intent and if approved, may develop full proposals. In this scenario, extramural investigators are required to identify an intramural collaborator on the project. On behalf of the lead extramural PI, the intramural investigator will be responsible for submitting both the letter of intent and full proposal electronically using proposalCentral.

Research proposals can fall into one of seven categories: AIDS, Behavioral and Social Sciences, Dietary Supplements, Minority Health and Health Disparities, Rare Diseases, Women's Health or General.

The Bench-to-Bedside program uses an electronic venue (proposalCentral) to aid investigators in submitting a letter of intent and in collaborating online with the project leader on developing a proposal for submission. Reviewers will also have access to online features to augment the review process.

For awards involving extramural partners, extramural funds will be directed as an administrative supplement to an existing grant. If indicated, the amount of funds to extramural investigators may be increased to cover indirect costs. Among other stipulations, the grant vehicle must be capable of receiving administrative supplements for two years and the support must be consistent with the approved aims and objectives of the grant. Principal investigators for all awarded projects will be required to submit annual progress reports on the project's status.

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This page last updated on 05/02/2018

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