Bench-to-Bedside Program

2006 Bench-to-Bedside Awards and Funded Projects

2006 Bench-to-Bedside Awards

NIH expands Initiative to Encourage Bench-to-Bedside Research

In 2006, the National Institutes of Health awarded nearly $4 million to fund 19 B2B medical research projects designed to speed translation of promising laboratory discoveries into new medical treatments. It was the first time applications for these awards, given since 1999, were open to research teams made up of NIH intramural and extramural collaborators from medical schools, health-care organizations and private industry. All but one of the funded projects include extramural partners; nine of the 19 projects involve researchers from two or more NIH institutes or centers.

The 2006 awards were made in four categories funded by the NIH Office of Rare Diseases; the NIH Office of AIDS Research; the National Center on Minority Health and Health disparities; and the NIH Office of Research on Women’s Health. A fifth category is co-funded by sponsoring institutes and, for the projects’ extramural components, the NIH National Center for Research Resources. Project teams receive up to $200,000 over two years to support their work.

Also in 2006, projects in minority health and health disparities and women’s health were specifically funded for the first time. Quality of the science, promise for becoming an active clinical trial, and potential for offering a new medical treatment or better understanding an important disease process were among selection criteria.

2006 Bench-to-Bedside Funded Projects

AIDS CATEGORY:

Project Institute or institution/Investigators
The effect of HIV-1 Infection on Endogenous miRNA Expression in vivo NIAID: Jeang, Kuan-Teh St. Michael's Medical Center: Smith, Stephen
Genetic Characteristics of HIV-1 During Suppressive Antiretroviral Therapy NCI: Maldarelli, Frank; Coffin, John; Palmer, Sarah; Weigand, Ann; Kearney, Mary Johns Hopkins University: Persaud, Deborah NIAID: Kottilil, Shyamasundaran
Evaluation of Molecular Methods for the non-invasive Diagnosis of Pneumocystis and Tuberculosis and Molecular Evaluation of Non-subtype B HIV Quasispecies in the Lung CC: Kovacs, Joseph; Fischer, Steven NCI: Maldarelli, Frank University of California, San Francisco: Huang, Laurence San Francisco General Hospital: Davis, J. Lucian SAIC: Imamichi, Hiromi Makerere University, Mulago Hospital: Worodria, William; Yoo, Samuel
Microalbuminuria and Podocyturia in Patients with HIV disease: Detection, Characterization, and Therapy NIDDK: Kopp, Jeffrey; Howard, Lilian Children's National Medical Center: McBryde, Kevin

RARE DISEASES CATEGORY:

Institute(s) Project
Role of Cyclin D1 in Myelodysplasia NHLBI: Sloand, Elaine; Young, Neal; Scheinberg, Phillip; Barrett, John CC: Kurlander, Roger Harvard University: Groopman, Jerome Georgetown University: Blancato, Jan National Naval Medical Center: More, Kenneth Salisbury District Hospital (UK): Crolla, John
Exploring the Anti-Tumor Effects of in vitro Expanded Natural Killer (NK) Cells Against Renal Cell Carcinoma Sensitized to NK-TRAIL Cytotoxicity with Bortezomib NHLBI: Childs, Richard; Lundqvist, Andreas CC: Read, E.J.; Suffredini, Anthony Walter Reed Army Medical Center: Gorak, Edward; Alvarez, Gauri
A New Global Function for a Rare Disease Gene: Clinical Significance of the Regulation of Mitochondrial Respiration by Tumor Suppressor p53 in Li-Fraumeni Syndrome NHLBI: Hwang, Paul
MD Anderson Cancer Center: Strong, Louise; Khakoo, Aarif; Arena, Ross
Therapeutic Approaches for Cancer Stem Cells in Small Cell Neuroendocrine Carcinomas NCI: Harris, Curtis; Varticovski, Lyuba; Dennis, Phillip A.; Bates, Susan
NHLBI: Dunbar, Cynthia
NINDS: McKay, Ron Memorial Sloan-Kettering
Cancer Center: Travis, William D.
High Density Genotyping in Diffuse Large B-cell Lymphoma (DLBCL) and Follicular Lymphoma – Translating Etiologic Clues into Prognostic Relevance Within the NCI-SEER NHL Case Control Study NCI: Chanock, Stephen; Wang, Sophia; Hartge, Patricia; Staudt, Lou; Morton, Lindsay; Wacholder, Sholom; Rothman, Nathaniel
Mayo Clinic College of Medicine: Cerhan, James
University of Southern California: Cozen, Wendy
Fred Hutchinson Cancer Research Center: Davis, Scott; Karmanos
Cancer Center & Wayne State University: Severson, Richard
Novel Suicide Gene-Modified Donor Th2 Cells for GVHD Prevention CC: Reed, Elizabeth J.; Carter, Charles
NCI: Fowler, Daniel
University of Toronto/Ontario Cancer Institute: Medin, Jeffrey
University of Illinois: Lavie, Arnon
A Nutrigenomics Intervention for the Study of the Role of Dietary Sitosterol on Lipid, Glucose and Energy Metabolism NIDDK: Celi, Francesco
NHLBI: Sachdev, Vandana
University of Maryland: Horenstein, Richard; Fried, Susan; Shuldiner, Alan
Pilot Trial of Intravenous Nitrite for Sickle Cell Vaso-Occlusive Pain Crisis NHLBI: Gladwin, Mark; Machado, Roberto; Taylor, James; Wang, Xunde
CC: Kato, Gregory
NIDDK: Schechter, Alan; Shiva, Sruti
NCI: Mack, Kyle
Drexel University: Hsu, Lewis

MINORITY HEALTH AND HEALTH DISPARITIES:

Project Institute or institution/Investigators
Hemolysis, HIV/AIDS and Parasitic Infections Associated Secondary Pulmonary Arterial Hypertension in Sickle Cell Diseases NHLBI: Aliyi, Zakari; Gladwin, Mark; Taylor, James, G.; Machado, Roberto
CC: Cato, Gregory 
NIDDK
: Rogers, Griffin
Novel Bench-to-Bedside Research Methods for Drug Addiction: Development, Validation and Application NIDA: Stein, Elliott
University of Pennsylvania: Childress, Anna Rose; Peoples, Laura
Breast Cancer among African American Women: The role of Missense Changes in the BRCA1 and BRCA2 Breast Cancer Susceptibility Genes Using a Population-Based Approach NHGRI: Ostrander, Elaine
Fred Hutchinson Cancer Research Institute: Malone, Kathleen
Melanocortin 3 receptor Mutations as an Etiology for Obesity in African American and Caucasian children NICHD: Yanovski, Jack; Ning, Cong; Koo, Ja-Shin; Westphal, Heiner J.
NIDDK: Gavrilova,
Oksana University of Wisconsin: Schoeller, Dale

WOMEN'S HEALTH

Project Institute or institution/Investigators
Vitamin E Pharmacokinetics and Oxidative Biomarkers in Normal and Obese Women NIDDK: Levine, Mark
Oregon State University: Traber, Maret

CO-FUNDED (INSTITUTE AND NCRR)

Project Institute or institution/Investigators
Immunosuppression Minimization by Biological Response Monitoring NIDDK: Kirk, Allen Washington
Hospital Center: Light, Jimmy
A Preliminary Assessment of the use of Ocular Coherence Tomography and Magnetic Resonance Imaging as Outcome Measures for Studying the Optic Nerve in Studies of Neuroprotection in Multiple Sclerosis NINDS: McFarland, Henry
NEI: Nussenblatt, Robert
Johns Hopkins School of Medicine: Calabresi, Peter
University of Pennsylvania: Balcer, Laura

Previous Awards Funded

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This page last updated on 06/12/2017

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