Dr. Frank Maldarelli discusses his project, "New Bioinformatic Approach to Determine HIV Incidence"
Dr. Manfred Boehm discusses his project, "Aneurysm Formation in Patients with Mutation of STAT3"
Dr. Jack Yanovski discusses his project, "FTO and Eating in the Absence of Hunger"
Team: NHLBI, NCI, CC, University of Pittsburgh
Project: "Hemolysis-Associated Hemostatic Activation in Sickle Cell Disease"
Investigators: G. Kato, NHLBI; D. Roberts, NCI; J. Lozier CC DLM; E. Novelli, J. Isenberg, M. Ragni, U of Pitt
A 2009 Bench-to-Bedside Award is funding a look at the potential contribution of special blood clotting proteins like thrombospondin and their role in regulating nitric oxide in blood vessels of patients with sickle cell disease, especially patients with sickle cell disease combined with pulmonary hypertension. The study of these two disorders is important because such a combination leads to a higher mortality rate, said project lead Dr. Gregory Kato (forefront), head of the Sickle Cell Vascular Disease Section in the National Heart, Lung and Blood Institute's Pulmonary and Vascular Medicine Branch.
The project is an interesting collaboration of hematologists who know about sickle cell disease; pulmonologists like Dr. Mark Gladwin (chief of the Pulmonary, Allergy and Critical Care Medicine Division at the University of Pittsburgh School of Medicine); blood clotting specialists like Dr. Jay Lozier (left, attending physician in the Clinical Center's Department of Laboratory Medicine); and other specialists at the Vascular Medicine Institute at the University of Pittsburgh, such as blood flow researcher Dr. Jeff Isenberg and Dr. Enrico Novelli, assistant professor and director of the Adult Sickle Cell Anemia Program.
Also involved at NIH are (from left): Dr. David Roberts (NCI), Laurel Mendelsohn (NHLBI), and Jim Nichols (CC).
Team: NIAID, NIDDK, Children's National Medical Center
Project: "Non-invasive cardiac 3T MRI for evaluation of premature coronary artery disease and myocardial dysfunction in adolescents and young adults with HIV acquired in infancy and childhood"
Investigators: C. Hadigan, MD, MPH, NIAID; A. Gharib, MD, NHLBI; R. Cross, MD, MS, CNMC; S. Clauss, MD, CNMC
Dr. Colleen Hadigan (middle), staff clinician in the National Institute of Allergy and Infectious Disease's Laboratory of Immunoregulation, is head of a team using the Clinical Center's cutting-edge imaging to identify early cardiovascular disease in young adults infected with HIV at birth.
The research is possible through a two-year 2008 Bench-to-Bedside Award. Hadigan's team includes (from left) Vijaya Thomas (NIAID), Jatin Matta (NIDDK), Dr. Ahmed Gharib (NIDDK), and Judy Purdy (CC).
Others involved in the study but not shown are Dr. Russell Cross and Dr. Sarah Clauss from Children's National Medical Center, and Dr. Rohan Hazra (NICHD) and Nancy Maldoon.
Team: NICHD, NIDDK, Sackler School of Med, Tel Aviv, Israel
Project: "Histaminergic pathways and energy intake in obese women"
Investigators: J. Yanovski, MD, PhD; L. Yanoff, MD, and C. Cropp, PharmD, NICHD
Dr. Jack Yanovski, head of the Unit on Growth and Obesity at the National Institute of Child Health and Human Development, is leading two Bench-to-Bedside Award teams examining genetic predispositions for weight gain.
"We are basically trying to relate specific genetic variations to behavior as part of our efforts to understand why some people have more difficulty maintaining a normal body weight," Yanovski said.
The award from 2008 allows the team to study if genes that affect histaminergic pathways are involved in human body weight regulation also and funds a dose-ranging clinical trial measuring energy intake in obese women given a medicine that acts like histamine in the brain. Yanovski's latest award backs a look at the connection between polymorphisms in the fat-mass-and-obesity-associated gene locus and the energy intake during buffet meals and during eating in the absence of true hunger (for example, after a satiating meal).
Working on these Bench-to-Bedside Award research projects are (from left): Abena Akomeah (NICHD), Ayelet Spitzer (NICHD), Nancy Sebring (CC), Dr. Asem Hassan Ali (NIDDK), Dr. Marian Tanofsky-Kraff (NICHD), Yanovski, Merel Kozlosky (CC), and Dr. Lauren Shomaker (NICHD).
Dr. Joan Han discusses her project, "WAGR Syndrome: Clinical Characterization and Correlation with Genotype"
Team: NICHD, Cleveland Clinic Genomic Medicine Institute
Project: "Genetics of inherited paragangliomas and gastric stromal tumors associated with adrenal and other tumors"
Investigators: C. Stratakis, MD, DMSc, NICHD; C. Eng, MD, PhD, Cleveland Clinic
Through a 2007 Bench-to-Bedside Award a team led by Dr. Constantine Stratakis (front left), head of the National Institute on Child Health and Human Development's Section on Endocrinology and Genetics, is researching the genetic causes of pediatric endocrine tumors.
The collaboration with the Cleveland Clinic and L'Hopital Cochin in Paris looks at "a form of multiple endocrine neoplasia that predisposes to a variety of endocrine and non-endocrine tumors," Stratakis said.
The NICHD team includes (clockwise from top right) Nirmal Gokarn, Dr. Madson Almeida, Dr. Anya Rothenbuhler, Dr. Anelia Horvath, Stratakis, Dr. Maria Nesterova, Dr. Fabio Faucz, and Kit Man Tsang.
NIDDK team examines effect of diet on vascular disease
Team: NIDDK, NHLBI, Harvard School of Public Health
Project: "Ethnic Differences in Triglyceride Levels and Vascular Disease: A Study of Premenopausal African American and Caucasian Women"
Investigators: A. Sumner, MD, NIDDK; Frank M. Sacks, MD, Harvard; V. Sachdev, MD, NHLBI; B. Denkinger, RD, CC Nutrition Department; M. Ricks, RN, NIDDK; M. Aikawa, MD, PhD, Brigham & Women's Hospital
A team led by Dr. Anne Sumner (sitting), researcher in the Clinical Endocrinology Branch of the National Institute of Diabetes and Digestive and Kidney Diseases, in collaboration with Dr. Vandana Sachdev from the National Heart, Lung, and Blood Institute and Dr. Frank M. Sacks from the Harvard School of Public Health, is studying the clinical, structural, and physiological reasons why there are ethnic differences in the effect of triglyceride-rich lipid particles on vascular disease.
The protocol, Effect of Diet on Vascular Disease, is funded through a 2007 Bench-to-Bedside Award for an intramural-extramural-cross institute collaboration.
Sumner's NIDDK team includes (from left): Anita Tambay, Marcella Luercio, Omoye Imoisili, Cassandra Camp, Madia Ricks, and Dr. Bernard Miller.
Bench-to-Bedside Program Expands (1.7 MB)
Smith-Magenis Syndrome (1.7 KB)
Novel Cancer Vaccine (1.7 MB)
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This page last updated on 06/13/2017