Dr. Alina E. Dulau-Florea is a hematopathologist whose expertise includes diagnosing a large variety of benign and malignant hematologic diseases in the bone marrow and lymph nodes, interpreting laboratory tests of coagulation and hemostasis, molecular testing of thrombophilia, as well as molecular assays for assessment of hematopoietic chimerism after stem cell transplantation.
Dr. Dulau-Florea earned her medical degree from the University of Medicine and Pharmacy of Targu-Mures in Romania in 1996. She then completed two years as a resident in Clinical Hematology.
In 2000, Dr. Dulau-Florea joined the laboratory of Dr. Mary Fabry at Albert Einstein College of Medicine as a Research Associate, where she studied pathologic changes in mouse models with sickle cell disease. While at Albert Einstein College of Medicine, Dr. Dulau-Florea completed her residency in Anatomic and Clinical Pathology, and also served as Chief resident. She then continued her training with fellowships in Hematopatholgy and Neuropathology.
In 2009, Dr. Dulau-Florea was appointed Assistant Professor at Thomas Jefferson University working as an attending hematopathologist.
She joined the Hematology Service in the Department of Laboratory Medicine at the NIH Clinical Center in 2014 as a senior research fellow, signing out bone marrows and molecular tests. In 2017, she was promoted to staff clinician, and more recently, Director of the Coagulation Laboratory.
Dr. Dulau-Florea’s professional interests include myelodysplastic syndromes in patients with germline predisposition, study of paroxysmal nocturnal hemoglobinuria associated with bone marrow failure, and the link between immune dysregulation and myeloid neoplasms. Other clinical interests include coagulation and hemostasis, with a focus on coagulation abnormalities in patients with cancer.
Galera P, Dulau-Florea A, Calvo KR. Inherited thrombocytopenia and platelet disorders with germline predisposition to myeloid neoplasia. Int J Lab Hematol. 2019, 41(S1):131-141.
Dulau Florea AE, Maric I, Calvo KR, Braylan RC. Detection of Paroxysmal Nocturnal Hemoglobinuria (PNH) in Bone Marrow Aspirates. Semin Hematol 2019 Jan;56(1):65-68.
Kallen ME, Dulau Florea A, Wang W, Calvo KR. Acquired and Germline Predisposition to Bone Marrow Failure: Diagnostic features and clinical implications. Semin Hematol 2019 Jan;56(1):69-82.
Dulau Florea AE, Young NS, Maric I, Calvo KR, Dunbar C, Winkler T, Townsley DM, Monreal M, Jiang C, Jordan EK, Braylan RC. Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria (PNH) Detection. Am J Clin Pathol. 2018 Jul 5;150(3)273-282.
Joneja U, Gulati G, Florea AD, Gong J. The Results of Hemoglobin Variant Analysis in Patients Revealing Microcytic Erythrocytosis on Complete Blood Count. Lab Medicine 2018 Mar 21;49(2):147-153.
Mikkilineni L, Whitaker-Menezes D, Domingo-Vidal M, Sprandio J, Avena P, Cotzia P, Dulau Florea A, Gong J, Uppal G, Zhan T, Leiby B, Lin Z, Pro B, Sotgia F, Lisanti M, Martinez-Outschoorn UE. Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment. Semin Oncol 2017 Jun;44(3):218-225.
Gooptu M, Whitaker-Menezes D, Sprandio J, Domingo-Vidal M, Lin Z, Uppal G, Gong J, Fratamico R, Leiby B, Dulau-Florea A, Caro J, Martinez-Outschoorn UE. Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B Cell lymphoma. Semin Oncol. 2017 Jun;44(3):204-217.
Dulau Florea AE, Braylan RC, Schafernak KT, Williams K, Pittaluga S, Holland SM, Uzel G, Calvo KR. Abnormal B-Cell Maturation in the Bone Marrow of Patients with Germline Mutations in PIK3CD. J Allergy Clin Immunol. 2017 Mar;139(3): 1032-1035.
Gulati G, Uppal G, Florea AD, Gong J. Detection of Platelet Clumps on Peripheral Blood Smears by CellaVision DM96 System and Microscopic Review. Lab Med. 2014 Fall;45(4):368-71.
Gulati G, Song J, Florea AD, Gong J. Purpose and criteria for blood smear scan, blood smear examination, and blood smear review. Ann Lab Med. 2013 Jan;33(1):1-7.
Martinez-Outschoorn UE, Whitaker-Menezes D, Valsecchi M, Martinez-Cantarin M, Dulau-Florea A, Gong J, Howell A , Flomenberg N, Pestell RG, Wagner J, Arana-Yi C, Sharma M, Sotgia F, Lisanti MP. Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome? Semin Oncol. 2013 Aug;40(4):403-18.
Gong P, Metrebian F, Dulau-Florea A, Wang ZX, Bajaj R, Gulati G, Peiper SC, Gong JZ. Aberrant expression of CD56 on granulocytes and monocytes in myeloproliferative neoplasm. J Hematopathol. 2013;6(3):127-34.
Bourne S, Ma N, Gulati G, Dulau Florea A
Sbenghe MM, Besa E, Mahipal A, Dulau Florea A, Bray P, Caro J. HHV-8-Associated Multicentric Castleman’s Disease in HIV-Negative Patient: A Novel Therapy for an Orphan Disease. Oncologist. 2012;17(1):145-6.
Sbenghe MM, Florea AD, Mather P, Gitelson E. Chronic myeloid leukemia following heart transplantation and immunosuppression with tacrolimus. Clin Adv Hematol Oncol. 2011 Aug;9(8):623-7.
Zhang H, Maitta RW, Bhattacharyya PK, Florea AD , Sen F, Wang Q, Ratech H. γ-Synuclein is a promising new marker for staining normal follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. Am J Surg Path. 2011;35(12):1857-65.
- NIH Clinical Center DLM Special Act Award, 2018
- Outstanding Achievement Award for Teaching of Medical Students: Leo M. Davidoff Society, Albert Einstein College of Medicine/Yeshiva University, 2006
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This page last updated on 05/17/2021