Research at the NIH Clinical Center

Medical Milestones - Clinical Center Firsts

Citations

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  53. Oral EA, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. NEJM. 2002, 346: 570-578. 

  54. Lee JS, Fitzgibbon E, Butman JA, et al. Normal vision despite narrowing of the optic canal in fibrous dysplasia. NEJM. 2002, 347: 1670-76.

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  59. Wei MI, Toure I, Glenn GM, et al. Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. J Med Genet. 2006, 43: 18-27. 

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  62. Pinto PA, Chung PH, Rastinehad AR, et al. Magnetic resonance imaging/ultrasound fusion guided prostate biopsy improves cancer cancer detection following transrectal ultrasound biopsy and correlates with multiparametric magnetic resonance imaging. J Urology. 2011, 186: 1281-5.

  63. Biesecker LG, Mullikin JC, Facio FM, et al. The ClinSeq Project: Piloting large-scale genome sequencing for research in genomic medicine. Genome Res. 2009, 19:1665-74.

  64. Johnson LA, Morgan RA, Dudley ME, et al. Gene Therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood. 2009, 114: 535-46.

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  70. Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP, Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME. (2011). Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 17(13), 4550-7.

  71. Sabatino M, Jiaqiang R, David-Ocampo V, et al. The establishment of a bank of stored bone marrow stromal cell products. Translational Med. 2012, 10:1-12.

  72. Baum BJ, Alevizos I, Zheng C, et al. Early responses to adenoviral-mediated transfer of the aquaporin-1 cdna for radiation-induced salivary hypofunction. PNAS. 2012, 109: 19403-7.

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  74. Olnes MJ, Scheinberg P, Calvo KR, et al. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. NEJM. 2012, 367: 11-19.

  75. Ratnayaka K, Faranesh AZ, Hansen MS, et al. Real-time mri-guided right heart catheterization adults using passive catheters. European Heart J. 2013, 34: 380-9.

  76. Snitkin ES, Zelazny AM, Thomas PJ, et al. Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing. Sci Transl Med. 2012, 148:1-9.

  77. Sibley CH, Plass N, Snow J, Wiggs EA, Brewer CC, King KA, Zalewski C, Kim HJ, Bishop R, Hill S, Paul SM, Kicker P, Phillips Z, Dolan JG, Widemann B, Jayaprakash N, Pucino F, Stone DL, Chapelle D, Snyder C, Butman JA, Wesley R, Goldbach-Mansky R. (2012). Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes. Arthritis Rheum., 64(7), 2375-86.

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  79. Roschewski M, Dunleavy K, Pittaluga S, Moorhead M, Pepin F, Kong K, Shovlin M, Jaffe ES, Staudt LM, Lai C, Steinberg SM, Chen CC, Zheng J, Willis TD, Faham M, Wilson WH. (2015) Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a correlative biomarker study. Lancet Oncology. 16(5), 541-9.

  80. NIH uses genome sequencing to help quell bacterial outbreak in Clinical Center (Aug. 22, 2012)

  81. NIH to Launch Human Safety Study of Ebola Vaccine Candidate (Aug. 28, 2014)

  82. NIH uses photon-counting CT scanner in patients for the first time (Feb. 24, 2016)

  83. Memoli MJ, Shaw PA, Han A, Czajkowski L, Reed S, Athota R, Bristol T, Fargis S, Risos K, Powers JH, Davey RT Jr, Taubenberger JK. (2016). Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model. mBio. 7(2).

  84. Boyerinas B, Jochems C, Fantini M, Heery CR, Gulley JL, Tsang KY, Schlom J. (2015). Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells. Cancer Immunol Res. 3(10):1148-57.

  85. MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis,N Engl J Med, 2020 Mar 5;382(10):917-928. doi: 10.1056/NEJMoa1910038. https://pubmed.ncbi.nlm.nih.gov/32130814/

  86. Neurofilament light as a biomarker in traumatic brain injury, Neurology, 2020 Aug 11;95(6):e610-e622. doi: 10.1212/WNL.0000000000009983. Epub 2020 Jul 8. https://pubmed.ncbi.nlm.nih.gov/32641538/

  87. NIH scientists develop faster COVID-19 test (Aug. 16, 2021)

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