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You can search the collection of research studies being conducted at the NIH Clinical Center at Search the Studies. In addition, provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.

Patient Recruitment

Have You Received Radiation Therapy for Cancer?

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Fatigue Following Cancer Treatment

The National Institutes of Health (NIH) Clinical Center is seeking people who completed radiation treatment for cancer to participate in a research study. People report significant fatigue during and months after completing radiation therapy. Researchers want to test if a one-time dose of the medication, ketamine, or an active drug (active placebo), that has similar side effects as ketamine, can reduce this fatigue. This is not a treatment study for fatigue nor for cancer. Study procedures and medications are provided at no cost. Travel costs for study visits will be reimbursed in accordance with NIH guidelines.

Study involves:

  • Six outpatient visits to the NIH Clinical Center and three follow-up phone calls
  • You will receive an infusion of either ketamine or an active drug (active placebo) that will take about six hours
  • About two weeks later you will receive an infusion of the opposite medication
  • You will complete questionnaires and computerized thinking tests
  • Portable hand-grip test
  • Blood samples

You may be eligible if you are:

  • At least 18 years old
  • At least three months after completing a localized radiation therapy for cancer
  • Have high fatigue based on the total score from a fatigue questionnaire

You may not be eligible if you:

  • Have abnormally high or low routine blood count results
  • Have a history of tuberculosis (TB)
  • Have HIV; hepatitis B or C
  • Have a chronic inflammatory disease such as rheumatoid arthritis
  • Received radiation to the head
  • Are pregnant or nursing

Location: The NIH Clinical Center, America's research hospital, is in Bethesda, Maryland. On the Metro red line (Medical Center stop).

For more information:
Call: 1-800-411-1222
TTY: 1-866-411-1010
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Or go online:
Refer to study # 15-NR-0037

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Institute of Nursing Research (NINR)

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This page last updated on 03/07/2019

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