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You can search the collection of research studies being conducted at the NIH Clinical Center at Search the Studies. In addition, provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.

Patient Recruitment

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

An NIH Research Study to Better Understand ME/CFS

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Researchers at the NIH Clinical Center seek individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to participate in a research study. ME/CFS is a disease for which an accurate diagnosis and effective treatment have remained elusive. Researchers want to better understand this condition.

You may be eligible, if you:

  • Are between the ages of 18 and 60
  • Are currently experiencing fatigue after recovering from an infectio
  • Have been experiencing persistent fatigue for the last 6 months to 5 years
  • Have medical documentation of an infection before developing ME/CFS
  • Experience post-exertional malaise (PEM)
  • Have completed the 7th grade or higher
  • Are able to stay at the NIH Clinical Center as an inpatient for screening and study visits

You may NOT be eligible, if you are:

  • Pregnant, breast feeding, or trying to become pregnant during the 6 month period of the study
  • Unable to undergo a magnetic resonance imaging (MRI) scan

Participation includes:

  • A pre-screening phone interview with the study team
  • A 5 -10 day inpatient visit with up to 8 hours of testing each day which includes:
    • brain imaging studies using MRI
    • blood, urine, saliva, and spinal fluid collection
    • a tilt table test
    • an activity diary to complete at home
  • Some participants will be eligible for a second 5 -10 day inpatient stay with 8 hours of testing each day and overnight measurements which include:
    • performing vigorous exercise for periods of 10 -15 minutes
    • sleeping in a room that measures how the body uses energy
    • having brain imaging studies, brain transcranial magnetic stimulation and collection of spinal fluid

No cost for study-related tests and procedures and you may receive compensation for your participation.

Location: The NIH Clinical Center, America’s Research Hospital, is located in Bethesda, Maryland on the Metro red line (Medical Center stop).

For more information:
NIH Clinical Center
Office of Patient Recruitment
TTY for the deaf or hard of hearing: 1-866-411-1010
Se habla español

Or go online:
Refer to study #16-N-0058

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Institute of Neurological Disorders and Stroke (NINDS)

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This page last updated on 03/07/2019

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