Call the Office of Patient Recruitment at 800-411-1222 to speak with one of our Information Specialists.
For those who are deaf, hard-of-hearing, or speech impaired, the Federal Relay Service provides free telecommunications relay services (TRS).
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Do You or Someone You Know Have Biliary Tract Carcinoma?
Testing Immune-based Strategies in Biliary Tract Cancers
Researchers at the National Institutes of Health (NIH) in Bethesda, Maryland are studying the use of an immunotherapy medication called Pembrolizumab, with two other chemotherapy medications, Capecitabine and Oxaliplatin. Oxaliplatin and Capecitabine are widely used to treat different types of gastrointestinal cancers. The researchers want to see if when these medications are used together, they will support the immune system to better fight cancer cells. Pembrolizumab targets PD-1, a protein found on T cells that helps control your body's immune system response. When PD-1 attaches to PD-L1 (a protein found on some cancer cells), it can stop T cells from killing the cancer cells. Therapies like Pembrolizumab can make it harder for cancer cells to hide from T cells, so that the immune system can find them and try to attack them. We hope this combination when given together, may result in a new a way of treating patients with biliary tract carcinoma (BTC).
- 18 years or older
- Patient must have confirmation of biliary tract carcinoma
- Patient previously treated for biliary tract carcinoma and it has metastasized
- Patient must have received, been intolerant of and/or refused at least one line of chemotherapy
- Patient who has undergone liver transplant
- Patient with known brain metastases
- History of chronic autoimmune disease
The NIH Clinical Center, America's Research Hospital located in Bethesda, MD Metro red line (Medical Center stop)
For more information:
NIH Clinical Center Office of Patient Recruitment
For those who are Deaf, Hard-of-Hearing, or Speech Impaired
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Or go online:
Refer to NIH study 17-C-0082
Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)
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This page last updated on 02/25/2020