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Patient Recruitment

Patients with Colorectal Cancer

Colorectal Cancer Research at NIH

medical illustration depicting a close-up of cells entering a colon

medical illustration depicting a close-up of cancer cells

This study will determine whether Pexastimogene Devacirepvec (Pexa-Vec), given in combination with Durvalumab, will cause tumors to shrink. Pexa-Vec is a vaccine used to help boost the immune system to attack and destroy the cancer cells in patients. Durvalumab targets PDL-1, a protein found on tumor cells that contributes to the tumors avoidance of the immune system.

Study Design:

  • Physical examination and questionnaire
  • Imaging assessments (computed tomographic scan (CT) or magnetic resonance imaging (MRI))
  • Study treatment will be divided into cycles each lasting approximately 28 days


  • Patients must have progressed on, been intolerant of, or refused prior treatment
  • Patients must have at least one focus of metastatic disease
  • Patient able to provide a tumor sample from a previous surgery to confirm patient's diagnosis. If a sample is not available, patient will need to have a biopsy of your tumor

The NIH Clinical Center is America's Research Hospital and is located in Bethesda, Maryland, on the Metro Red line (Medical Center stop).

For more information:
NIH Clinical Center Office of Patient Recruitment
800-877-8339 TTY / ASCII
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Or go online:
Refer to NIH study # 17-C-0092

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)

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This page last updated on 03/09/2020

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