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You can search the collection of research studies being conducted at the NIH Clinical Center at Search the Studies. In addition, provides patients, family members, and members of the public easy and free access to information on clinical studies for a wide range of diseases and conditions.

Patient Recruitment

An Open-Label, Phase I/II Pilot Study to Assess the Safety and Tolerability of Vorinostat for the Treatment of Moderate-to-Severe Crohn's Disease

Do you have uncontrolled Crohn's disease?

medical illustration of a stomach

a man holding his stomach in pain

Researchers at the National Institutes of Health (NIH) are investigating whether a novel medication, vorinostat, may be used to successfully reduce inflammation and symptoms in people with Crohn's disease who fail to respond to traditional treatment.

What is involved?

  • The study has three parts- screening, treatment, and post-evaluation.
  • You will take the study medication, vorinostat, as a pill twice a day for up to 12 weeks.
  • You will have frequent study visits for evaluations and testing.
  • Clinical information will be shared with you and your doctor.
  • Medication, tests, and procedures conducted at the NIH Clinical Center are at no cost to you.

You may be eligible to participate if you:

  • Are 18-65 years or older.
  • Have been treated for Crohns's disease but you still experience symptoms.
  • Are willing to participate in a study that may last more than a year.
  • Willing to take a novel medication.

Location: The NIH Clinical Center, America's research hospital, is conveniently located on the Metro Red Line (Medical Center stop) in Bethesda, Maryland.

For more information, call:
Office of Patient Recruitment
TTY: 1-866-411-1010
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Or go online:
Refer to study #17-I-0101

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Institute of Allergy and Infectious Diseases (NIAID)

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This page last updated on 03/07/2019

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