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Patient Recruitment

Does adding 1-2 experimental therapies improve treatment of GBM?

NIH Brain Cancer Research

a man riding a bike

National Cancer Institute researchers in Bethesda, Maryland, are enrolling participants in the very first study of its kind for a type of brain cancer called glioblastoma or GBM. This research study is testing if adding 1-2 experimental therapies (HSPPC-96 or placebo vaccine and pembrolizumab) improves standard treatment for GBM. All treatment and research procedures are provided at no cost. Travel assistance provided for enrolled participants.

During the study:

  • After brain surgery at the NIH to remove as much of the tumor as possible, patients will receive the standard treatment for GBM: radiation treatment, and temozolomide (TMZ), an oral chemotherapy drug.
  • All patients will also receive an immunotherapy agent called pembrolizumab. The combination of pembrolizumab with standard treatment has been shown to be well-tolerated.
  • Some patients will also receive a vaccine made from part of their own tumor. Researchers want to see if adding this personalized cancer vaccine (HSPPC-96) will improve the effect of pembrolizumab.

You may be eligible if you:

  • Are an adult who has been recently diagnosed with GBM or have a suspected GBM and are eligible to undergo surgery at the NIH
  • Have not already received radiation, chemotherapy or carmustine wafers for your GBM

Location: The NIH Clinical Center, America's research hospital, is conveniently located on the Metro Red Line (Medical Center stop) in Bethesda, Maryland.

For more information, call:
Office of Patient Recruitment
TTY: 1-866-411-1010
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Or go online:
Refer to study #17-C-0034 or NCT03018288

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)

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This page last updated on 03/07/2019

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