Biomedical Specimens - Resources

Please use the links below to learn more about specific research resources at the NIH Clinical Center and Intramural Program.

Biologics for Research

Description Point of Contact Link

This initiative, in the Department of Transfusion Medicine, involves collection of whole blood, leukocytes, plasma, etc. from random or phenotyped normal individuals for use in laboratory research.

Cathy Cantilena, M.D.
Ccantilena@cc.nih.gov
301.451.8637

http://www.cc.nih.gov/
dtm/index.html

Hyperimmune Plasma from Post Recovery or Vaccinated Subjects

Description Point of Contact Link

The Department of Transfusion Medicine has apheresis equipment capable of collecting a variety of components from patients or normal research subjects. Large volumes of plasma and/or immune cells can be provided. Serial collections are possible.

Cathy Cantilena, M.D.
Ccantilena@cc.nih.gov
301.451.8637

http://www.cc.nih.gov/
dtm/index.html

Red Blood Cell (RBC), HLA and KIR Antigens by Serology and Full Length Nucleotide Sequencing

Description Point of Contact Link

TThe Department of Transfusion Medicine has state-of-the art technology for molecular immunohematology of blood cell genes and their blood cell surface antigen expression. A special emphasis is red cell genotyping. These assays can be used for reference purposes or for clinical research.

Willy Flegel, M.D.
bill.flegel@nih.gov
301.594.7401

http://www.cc.nih.gov/dtm/our_research.html

Bacterial Endotoxin for Human Clinical Research

Description Point of Contact Link

Endotoxin administration to humans provides a means to investigate mechanisms of human inflammation, proof of principle for the effects of inflammatory-modulating therapies, and serves as a potent stimulus to enhance immune responses in trials of immunotherapy for cancer. The Clinical Center provides GMP grade endotoxin to qualified investigators for these studies.

Anthony F. Suffredini, M.D.
ASuffredini@cc.nih.gov
301.402.3485

http://clinicalcenter.nih.gov/about/
SeniorStaff/anthony_suffredini.html

Bone Marrow Stromal Cells, Production and Banking

Description Point of Contact Link

The Department of Transfusion Medicine has an initiative to produce Bone Marrow Stromal Cells (BMSCs) from healthy subjects which will be used to treat patients with a variety of conditions. Possible applications include treatment of acute graft versus host disease, marrow failure, organ failure following allogeneic stem cell transplantation, coronary artery disease, treatment of chronic graft versus host disease, inflammatory bowel disease, and multiple sclerosis.

Dr. David Stroncek
DStroncek@cc.nih.gov
301.496.9702

http://clinicalcenter.nih.gov/dtm/
our_research.html
#laboratory_services

Novel Cellular Biologics for Phase I/II Trials

Description Point of Contact Link

The Department of Transfusion Medicine has expertise in scaling up novel cellular biologicals (gene corrected cells, T-cell subsets, dendritic cells, cellular vaccines, etc.) for human use.

David Stroncek, M.D.
DStroncek@cc.nih.gov
301.496.9702

http://clinicalcenter.nih.gov/dtm/
our_research.html
#laboratory_services

PET Radiotracer/Ligand Synthesis: Radiopharmaceuticals

Description Point of Contact Link

The Positron Emission Tomography Department has extensive resources which include hot cells to manufacture radiopharmaceuticals for PET imaging. We currently synthesize several PET radiopharmaceuticals used in intramural clinical research protocols under IND or Radioactive Drug Research Committee authorization. A PET cGMP facility under construction will manufacture PET research radiopharmaceuticals for human use in compliance with recent FDA regulations.

Peter Herscovitch, M.D.
PHerscovitch@cc.nih.gov
301.451.4248

http://clinicalcenter.nih.gov/
pet/index.html

Pharmacokinetic Core

Description Point of Contact Link

The NCI Pharmacokinetic Core provides pharmacokinetic analysis and storage of specimens to all investigators within CCR, potentially to collaborators as well.

William Douglas Figg, Pharm D
figgw@mail.nih.gov
301.402.3622

http://ccr.cancer.gov/labs/
lab.asp?labid=106

Multipotential Progenitor Cells (Cell Culture Model of Developing Brain)

Description Point of Contact Link

Human brain derived multipotential progenitor cells have been identified, isolated and propagated in culture from various gestational ages. The progenitor cells can be directed to different lineages by providing extracellular signals as growth factors in order to direct differentiation to astrocytes, neurons, or oligodendrocytes. The progenitor cells can be maintained through many cell divisions when propagated under culture conditions using specific stem cell factors.

Gene Major, Ph.D.
majorg@ninds.nih.gov
301.496.1635

http://neuroscience.nih.gov/
Lab.asp?Org_ID=530

Skin Fibroblasts – Cell Biology Section

Description Point of Contact Link

The NINDS Cell Biology Section, Neurogenetics Branch evaluates patients with a large variety of different genetic forms of hereditary spastic paraplegia. They are generating fibroblast cell lines from skin biopsies for many of these genetic subtypes.

Craig Blackstone, M.D., Ph.D.
blackstc@ninds.nih.gov
301.451.9680

http://www.ninds.nih.gov/
research/labs/410.htm

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This page was last updated: 01/26/2017