Radiology and Imaging Sciences

Staff Pages

Daniel S. Reich, MD, PhD
Translational Neuroradiology Unit
Neuroimmunology Branch
National Institute of Neurological Disorders and Stroke

Radiology and Imaging Sciences

Academic Degrees
BS, Yale University
PhD, The Rockefeller University
MD, Cornell University


Phone: 301-496-1801


Dr. Reich earned his medical degree at Cornell University’s Weill Medical College as part of the Medical Scientist Training Program and his PhD in neurophysiology from The Rockefeller University, where he studied the ways in which nerve cells encode and process visual information. He also holds an undergraduate degree in mathematics and physics from Yale University. His training includes a fellowship in diagnostic neuroradiology at the Johns Hopkins School of Medicine and residencies in radiology and neurology at the Johns Hopkins Hospital. In addition to his primary affiliation at NIH, Dr. Reich is also Adjunct Assistant Professor of Radiology and Neurology at the Johns Hopkins School of Medicine.

Dr. Reich directs the Translational Neuroradiology Unit within the Neuroimmunology Branch of the National Institute of Neurological Disorders and Stroke. Research in his lab focuses on the use of advanced magnetic resonance imaging techniques to understand the sources of disability in multiple sclerosis and on ways of adapting those techniques for use in research trials and routine patient care. He is particularly interested in harnessing non-invasive imaging modalities to dissect biological mechanisms of tissue damage.

Dr. Reich is actively involved in training junior scientists and physicians. Trainees in his lab include postdoctoral and clinical fellows, graduate and medical students, and high school summer students.

Dr. Reich is board-certified in diagnostic radiology and neurology, has earned a Certificate of Added Qualification in neuroradiology, and holds a medical license in the state of Maryland.

Selected Publications

To date, Dr. Reich has co-authored nearly 50 peer-reviewed papers and over 100 scientific abstracts. He is a reviewer for more than 10 scientific journals and has presented over 30 invited lectures nationally and internationally.

Sati P, Silva AC, van Gelderen P, Gaitán MI, Wohler JE, Jacobson S, Duyn JH, Reich DS. In vivo quantification of T2* anisotropy in white matter fibers in marmoset monkeys. Neuroimage 2011; in press. doi:10.1016/j.neuroimage.2011

van Gelderen P, de Zwart JA, Lee J, Sati P, Reich DS, Duyn JH. Non-exponential T2* decay in white matter. Magn Reson Med 2011; in press. doi:10.1002/mrm.22990

Smith SA, Williams ZR, Ratchford JN, Newsome SD, Farrell SK, Farrell JAD, Gifford A, Miller NR, van Zijl PCM, Calabresi PA, Reich DS. Diffusion tensor imaging of the optic nerve in multiple sclerosis: Association with retinal damage and visual disability. AJNR Am J Neuroradiol 2011; 32:1662-1668. doi:10.3174/ajnr.A2574

Gaitán MI, Shea CD, Evangelou IE, Stone RD, Fenton KM, Bielekova B, Massacesi L, Reich DS. Evolution of the blood­brain barrier in newly forming multiple sclerosis lesions. Ann Neurol 2011; 70:22-29. doi:10.1002/ana.22472

Bazin P-L, Ye C, Bogovic JA, Shiee N, Reich DS, Prince JL, Pham DL. Direct segmentation of the major white matter tracts in diffusion tensor images. Neuroimage 2011; 58:458-468. doi:10.1016/j.neuroimage.2011.06.020

Shinohara RT, Crainiceanu CM, Caffo BS, Gaitán MI, Reich DS. Population-wide principal component-based quantification of blood-brain-barrier dynamics in multiple sclerosis. Neuroimage 2011; 57:1430-1446. doi:10.1016/j.neuroimage.2011.05.038

Goldsmith J, Crainiceanu CM, Caffo BS, Reich DS. Penalized functional regression analysis of white-matter tract profiles in multiple sclerosis. Neuroimage 2011; 57:431-439. doi:10.1016/j.neuroimage.2011.04.044

Goldsmith J, Caffo BS, Crainiceanu C, Reich DS, Du Y, Hendrix C. Nonlinear tube-fitting for the analysis of anatomical and functional structures. Annals of Applied Statistics 2011;5:337-363. doi:10.1214/10-AOAS384

Dasenbrock HH, Smith SA, Ozturk A, Farrell SK, Calabresi PA, Reich DS. Diffusion tensor imaging of the optic tracts in multiple sclerosis: Association with retinal thinning and visual disability. J Neuroimaging 2011;21:e41-e49. doi:10.1111/j.1552-6569.2010.00468.x

Harrison DM, Caffo BS, Shiee N, Farrell JAD, Bazin P-L, Farrell SK, Ratchford JN, Calabresi PA, Reich DS. Longitudinal changes in diffusion-tensor-based quantitative MRI in multiple sclerosis. Neurology 2011;76:179-186. doi:10.1212/WNL.0b013e318206ca61

Smith SA, Jones CK, Gifford A, Belegu V, Chodkowski BA, Farrell JAD, Landman BA, Reich DS, Calabresi PA, McDonald J, van Zijl PCM. Reproducibility of tract-specific magnetization transfer and diffusion tensor imaging in the cervical spinal cord at 3 Tesla. NMR in Biomedicine 2010;23:207-217. doi:10.1002/nbm.1447

Reich DS, Ozturk A, Calabresi PA, Mori S. Automated vs. conventional tractography in multiple sclerosis: Variability and correlation with disability. Neuroimage 2010;49:3047-3056. doi:10.1016/j.neuroimage.2009.11.043

Ozturk A, Smith SA, Gordon-Lipkin EM, Harrison DM, Shiee N, Pham DL, Caffo BS, Calabresi PA, Reich DS. MRI of the corpus callosum in multiple sclerosis: association with disability. Multiple Sclerosis 2010;16:166-177. doi:10.1177/1352458509353649

Shiee N, Bazin P-L, Ozturk A, Calabresi PA, Reich DS, Pham DL. A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions." Neuroimage 2010;49:1524-1535. doi:10.1016/j.neuroimage.2009.09.005

Reich DS, Smith SA, Gordon-Lipkin EM, Ozturk A, Caffo BS, Balcer LJ, Calabresi PA. Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability. Arch Neurol 2009;66:998-1006.

Reich DS, Mechler F, Victor JD. Independent and redundant information in nearby cortical neurons. Science 2001;294:2566-2568.

Reich DS, Mechler F, Purpura KP, Victor JD. Interspike intervals, receptive fields, and information encoding in primary visual cortex. J Neurosci 2000;20:1964-1974.

Reich DS, Victor JD, Knight BW, Ozaki T, Kaplan E. Response variability and timing precision of neuronal spike trains in vivo. J Neurophysiol 1997;77:2836-2841.

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