Radiology and Imaging Sciences

Center for Infectious Disease Imaging (CIDI)

The Center for Infectious Disease Imaging (CIDI) is a cooperative initiative between Radiology and Imaging Sciences at the NIH Clinical Center and the National Institute of Allergy and Infectious Diseases (NIAID). CIDI was established in 2009 to perform basic science, translational, and clinical research on the imaging features of infectious disease, including CT, nuclear medicine, MRI, ultrasound, radiography, and optical modalities. These efforts comprise a new initiative at NIH to advance the knowledge of radiology-pathology-virology correlation with clinical translation in the study of infectious disease and emerging pathogens. The Integrated Research Facility (IRF) supported by NIAID in conjunction with CIDI offers opportunities for intramural NIH and extramural investigators to collaborate on infectious disease research using advanced imaging technologies.

Major CIDI Program components include:

  • Collaborative partnerships with advanced containment laboratories with imaging capability at NIH campuses, including Fort Detrick, Bethesda, and Poolesville,
  • Basic, translation and clinical research on various pathogens, including high consequence viruses, HIV, fungal and bacterial infections,
  • Interdisciplinary training and education on molecular imaging applied to infectious disease research,
  • Animal model research for investigating pathophysiology, innovative imaging techniques, and development of drugs and vaccines,
  • Quantitative and computer-assisted-detection method development for assessing infectious disease severity and response to therapy.

The Center for Infectious Disease Imaging also provides a forum for regular dialog between radiologic and infectious disease researchers for new research design, clinical consultation, and medical education. Research fellows, post-docs, students, and visiting scholars are invited to participate in CIDI.

Slide of 4 CT scans. See caption for more.
Graphic shows examples of research from CIDI, including four CT scans of individuals with novel H1N1 influenza during the 2009 pandemic, demonstrating ground glass opacities and consolidations representing active sites of disease.
View Larger Graphic (100 KB)
Illustration of a cell. See caption for more.
Graphic shows an illustration of a cell with possible targets for molecular probes in potentially researching and diagnosing infectious disease. Commonly researched targets are shown, such as cell receptors, enzyme modified radiotracers, and theoretical probes for binding amino acids and genetic material.
View Larger Graphic (86 KB)

CIDI leadership

The co-directors for CIDI are Dr. Joseph Frank and Dr. H. Clifford Lane.

Dr. Dima Hammoud is a tenure-track investogator in CIDI.

Scientists/Physicians/groups working and/or collaborating on CIDI-related initiatives include:

  • Joseph A. Frank, MS, MD, NIH Clinical Center, Radiology and Imaging Sciences
  • H. Clifford Lane, MD, National Institute of Allergy and Infectious Disease (NIAID)
  • Dima Hammoud, MD, NIH Clinical Center, Radiology and Imaging Sciences
  • Irwin Feuerstein, MD National Institute of Allergy and Infectious Disease (NIAID), Integrated Research Facility (IRF)
  • Peter Jahrling, PhD, National Institute of Allergy and Infectious Disease (NIAID), Integrated Research Facility (IRF)
  • Daniel J. Mollura, MD, NIH Clinical Center, Radiology and Imaging Sciences
  • Jeffrey Solomon, PhD Integrated Research Facility (IRF)
  • Michele Di Mascio, PhD Integrated Research Facility (IRF)
  • Integrated Research Facility: CIDI has established multiple collaborative projects with various teams at the integrated research facility, a BSL4 high containment facility located in Fort Detrick, Frederick, MD.
Important links:

Office of AIDS Research

World Molecular Imaging Society: Imaging of Infections (IOI) Interest Group

Society of Nuclear Medicine and Molecular Imaging

<< Back to Top >>


Infectious Disease: A world-wide problem 

Infectious diseases Annual deaths (million)
Respiratory infections 3.96
HIV/AIDS 2.77
Diarrheal diseases 1.80
Tuberculosis 1.56
Vaccine-preventable childhood Diseases 1.12
Malaria 1.27
STDs (other than HIV) 0.18
Meningitis 0.17
Hepatitis B and C 0.16
Tropical parasitic diseases 0.13
Dengue 0.02
Other infectious diseases 1.76

Infectious diseases are responsible for more than 25% of 57 million annual deaths worldwide.

2/3 of nine million pediatric deaths yearly are from infectious disease.

Source:  World Health Organization and Morens DM, et al. The challenge of emerging and re-emerging infectious diseases, Nature 2004; 8: 242-249.

<< Back to Top >>

NOTE: PDF documents require the free Adobe Reader.

This page last updated on 10/13/2017

You are now leaving the NIH Clinical Center website.

This external link is provided for your convenience to offer additional information. The NIH Clinical Center is not responsible for the availability, content or accuracy of this external site.

The NIH Clinical Center does not endorse, authorize or guarantee the sponsors, information, products or services described or offered at this external site. You will be subject to the destination site’s privacy policy if you follow this link.

More information about the NIH Clinical Center Privacy and Disclaimer policy is available at http://www.cc.nih.gov/disclaimers.html